Synthesis and characterization of antibacterial activity from Danazol-aminoca- proic acid derivative on both gram negative and gram positive bacteria

In this work, danazol-aminocaproic acid derivative was synthesized and their antibacterial activity on both Gram negative and Gram positive bacteria was evaluated, using dilution method and the minimum inhibitory concentration (MIC). The results indicate that bacterial growth of S. aureus was inhibited in presence of danazolderivative (MIC=1.04 x 10-3 mmol). Additionally, another data showed that E. coli was susceptibly to danazolaminocaproic acid derivative with a MIC of 2.08 x 10-3 mmol. Finally, the growth bacterial of K. pneumoniae was blocked in presence of danazol-derivative (MIC=2.08 x 10-3 mmol). In conclusion, experimental data suggest that molecular mechanism involved in the antibacterial activity induced by danazol-derivative could be because the steroid require of the hydrophilic region of spacer arm with free carboxyl group, in order to interact with some factors of the cell surface and integrate into the cytoplasmic membrane and induce growth bacterial inhibition.