Synthesis and biological activity of fibrate-based acyl- and alkyl-phenoxyacetic methyl esters and 1,2-dihydroquinolines

Abraham Pucheta, Aarón Mendieta, Damián A. Madrigal, Roberto I. Hernández-Benitez, Liseth Romero, Leticia Garduño-Siciliano, Catalina Rugerio-Escalona, María C. Cruz-López, Fabiola Jiménez, Alejandra Ramírez-Villalva, Aydeé Fuentes-Benites, Carlos González-Romero, Omar Gómez-García, Julio López, Miguel A. Vázquez, Blanca Rosales-Acosta, Lourdes Villa-Tanaca, Alfonso Sequeda-Juárez, Eva Ramón-Gallegos, Germán Chamorro-CevallosFrancisco Delgado, Joaquín Tamariz

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. A series of highly potent antihyperlipidemic agents constituted by a fibrate-based structure was recently reported by our group, whose synthesis started from isovanillin derivatives. In the interest of evaluating the bioisosteric effect of the vanillin-based isomers on their antihyperlipidemic activity, the present study focuses on the synthesis of 5-acyl-1-phenoxyacetic methyl esters 5a–c and their saturated side-chain 5-alkyl-1-phenoxyacetates 6a–c. Their strong in vivo effect was associated with the inhibition of HMG-CoA reductase. Since 1,2-dihydroquinolines inhibit this enzyme, a series of such heterocycles (9a–d) was prepared by our efficient regioselective, one-step, solvent-free method. Apart from showing hypolipidemic activity in vivo, some of the compounds displayed antifungal, antioxidant and cytotoxic activity in vitro. The binding mode of four compounds at the active site of HMGRh was examined with docking simulations, observing an interaction with most of the amino acids targeted by simvastatin.
Original languageAmerican English
Pages (from-to)459-478
Number of pages20
JournalMedicinal Chemistry Research
DOIs
StatePublished - 1 Mar 2020

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