TY - JOUR
T1 - Synthesis and anti-inflammatory activity evaluation of unsymmetrical selenides
AU - Martínez-Ramos, Federico
AU - Salgado-Zamora, Hector
AU - Campos-Aldrete, Maria Elena
AU - Melendez-Camargo, Estela
AU - Márquez-Flores, Yazmín
AU - Soriano-García, Manuel
N1 - Funding Information:
The authors wish to thank Zavala Segovia Maria De Las Nieves (Instituto de Química, UNAM, México) for the NMR determinations. This work was partially supported by the Secretaria de Investigación y Posgrado, IPN.
PY - 2008/7
Y1 - 2008/7
N2 - The alkylation reaction of 2,2′-diseleno and 4,4′-diseleno-bis(benzoic acid) derivatives in the presence of sodium borohydride and alkyl halides allowed the synthesis of various new o- and p-alkylselenenylated benzoic acid derivatives in good yields. The anti-inflammatory activity of selected selenide derivatives on granuloma induced by subcutaneous implantation of cotton pellets in Wistar rats was examined. Selenium derivatives 2a, 2c and 2e showed anti-inflammatory activity although to a lesser extent as compared to indomethacin, however they were found less toxic than the latter.
AB - The alkylation reaction of 2,2′-diseleno and 4,4′-diseleno-bis(benzoic acid) derivatives in the presence of sodium borohydride and alkyl halides allowed the synthesis of various new o- and p-alkylselenenylated benzoic acid derivatives in good yields. The anti-inflammatory activity of selected selenide derivatives on granuloma induced by subcutaneous implantation of cotton pellets in Wistar rats was examined. Selenium derivatives 2a, 2c and 2e showed anti-inflammatory activity although to a lesser extent as compared to indomethacin, however they were found less toxic than the latter.
KW - Alkylselenenyl benzoic acid derivatives
KW - Anti-inflammatory activity
KW - Granuloma bioassay
UR - http://www.scopus.com/inward/record.url?scp=45949093587&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2007.09.029
DO - 10.1016/j.ejmech.2007.09.029
M3 - Artículo
SN - 0223-5234
VL - 43
SP - 1432
EP - 1437
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 7
ER -