TY - JOUR
T1 - Synergistic interaction between B vitamins and statins to counter nociception in rats
AU - Skiold, López Canales Jorge
AU - Estefania, Ruiz Pedraza Paola
AU - Carolina, García Paz María Paola
AU - Mery, López Mayorga Ruth
AU - Fernando, Castillo Henkel Enrique
AU - Jair, Lozano Cuenca
N1 - Publisher Copyright:
© 2020 Wiley Periodicals, LLC.
PY - 2021/5
Y1 - 2021/5
N2 - Evidence suggests that the antinociceptive activity of various drugs can be increased when administered in combination with B vitamins (BVs). The aim of this study was to examine the potential interaction between statins and BVs to counter nociception, the latter measured by the formalin test. Rats were orally administered atorvastatin (1, 3, 10 and 30 mg/kg), pravastatin (1, 3, 10 and 30 mg/kg), rosuvastatin (1, 3, 10 and 30 mg/kg), BVs (31, 56, 100 and 180 mg/kg) or calculated combinations of BVs with each drug. The effective dose 30 (ED30) was calculated for each statin and BVs and subjected to isobolographic analysis, thus finding the ED30 of the combinations. The antinociceptive experimental ED30 values for BVs administered with atorvastatin, pravastatin or rosuvastatin were 1.53 ± 0.38, 6.74 ± 0.04 and 4.26 ± 0.39, respectively, being lower (p <.05) than the corresponding theoretical ED30: 28.02 ± 2.20, 28.17 ± 2.20 and 29.86 ± 2.21. Since BVs likely boost the antinociceptive effect of statins, these combinations could possibly be advantageous in pain management.
AB - Evidence suggests that the antinociceptive activity of various drugs can be increased when administered in combination with B vitamins (BVs). The aim of this study was to examine the potential interaction between statins and BVs to counter nociception, the latter measured by the formalin test. Rats were orally administered atorvastatin (1, 3, 10 and 30 mg/kg), pravastatin (1, 3, 10 and 30 mg/kg), rosuvastatin (1, 3, 10 and 30 mg/kg), BVs (31, 56, 100 and 180 mg/kg) or calculated combinations of BVs with each drug. The effective dose 30 (ED30) was calculated for each statin and BVs and subjected to isobolographic analysis, thus finding the ED30 of the combinations. The antinociceptive experimental ED30 values for BVs administered with atorvastatin, pravastatin or rosuvastatin were 1.53 ± 0.38, 6.74 ± 0.04 and 4.26 ± 0.39, respectively, being lower (p <.05) than the corresponding theoretical ED30: 28.02 ± 2.20, 28.17 ± 2.20 and 29.86 ± 2.21. Since BVs likely boost the antinociceptive effect of statins, these combinations could possibly be advantageous in pain management.
KW - B vitamins
KW - analgesia
KW - formalin test
KW - isobolographic analysis
KW - pain
KW - pharmacology
KW - statins
UR - http://www.scopus.com/inward/record.url?scp=85097487448&partnerID=8YFLogxK
U2 - 10.1002/ddr.21767
DO - 10.1002/ddr.21767
M3 - Artículo
C2 - 33305435
AN - SCOPUS:85097487448
SN - 0272-4391
VL - 82
SP - 440
EP - 447
JO - Drug Development Research
JF - Drug Development Research
IS - 3
ER -