1H and 13C NMR study of the molecular interaction mechanism between chloramphenicol and human serum albumin

V. Panov; I. Shipanova; A. Michtchenko; I. Shabunin; N. Shimanovskii; L. Sibeldina; P. Sergeev

¹H and ¹³C NMR study of the molecular interaction mechanism between chloramphenicol and human serum albumin

V. Panov, I. Shipanova, A. Michtchenko, I. Shabunin, N. Shimanovskii, L. Sibeldina, P. Sergeev

Research output: Contribution to journal › Article › peer-review

Abstract

Molecular mechanism of the interaction between human serum albumin and cloramphenicol was studied by ¹H and ¹³C NMR-spectroscopy. It was found that the main role belongs to -CH-NH, -CHCl₂ and -C-NO₂ groups of chloramphenicol. A schematic model of the complex-formation between serum albumin and chloramphenicol was proposed.

Original language	English
Pages (from-to)	457-460
Number of pages	4
Journal	Biochemistry and Molecular Biology International
Volume	35
Issue number	2
State	Published - 1995
Externally published	Yes

Cite this

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title = "1H and 13C NMR study of the molecular interaction mechanism between chloramphenicol and human serum albumin",

abstract = "Molecular mechanism of the interaction between human serum albumin and cloramphenicol was studied by 1H and 13C NMR-spectroscopy. It was found that the main role belongs to -CH-NH, -CHCl2 and -C-NO2 groups of chloramphenicol. A schematic model of the complex-formation between serum albumin and chloramphenicol was proposed.",

author = "V. Panov and I. Shipanova and A. Michtchenko and I. Shabunin and N. Shimanovskii and L. Sibeldina and P. Sergeev",

year = "1995",

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T1 - 1H and 13C NMR study of the molecular interaction mechanism between chloramphenicol and human serum albumin

AU - Panov, V.

AU - Shipanova, I.

AU - Michtchenko, A.

AU - Shabunin, I.

AU - Shimanovskii, N.

AU - Sibeldina, L.

AU - Sergeev, P.

PY - 1995

Y1 - 1995

N2 - Molecular mechanism of the interaction between human serum albumin and cloramphenicol was studied by 1H and 13C NMR-spectroscopy. It was found that the main role belongs to -CH-NH, -CHCl2 and -C-NO2 groups of chloramphenicol. A schematic model of the complex-formation between serum albumin and chloramphenicol was proposed.

AB - Molecular mechanism of the interaction between human serum albumin and cloramphenicol was studied by 1H and 13C NMR-spectroscopy. It was found that the main role belongs to -CH-NH, -CHCl2 and -C-NO2 groups of chloramphenicol. A schematic model of the complex-formation between serum albumin and chloramphenicol was proposed.

UR - http://www.scopus.com/inward/record.url?scp=0029416877&partnerID=8YFLogxK

M3 - Artículo

C2 - 7663402

AN - SCOPUS:0029416877

SN - 1039-9712

VL - 35

SP - 457

EP - 460

JO - Biochemistry and Molecular Biology International

JF - Biochemistry and Molecular Biology International

IS - 2

ER -

¹H and ¹³C NMR study of the molecular interaction mechanism between chloramphenicol and human serum albumin

Abstract

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