TY - JOUR
T1 - Study of perinatal transmission of SARS-CoV-2 in a Mexican public hospital
AU - Ramírez-Rosas, Adriana
AU - Benitez-Guerrero, Tizziani
AU - Corona-Cervantes, Karina
AU - Vélez-Ixta, Juan Manuel
AU - Zavala-Torres, Norma Gabriela
AU - Cuenca-Leija, Jazmin
AU - Martínez-Pichardo, Sarahi
AU - Landero-Montes-de-Oca, María Esther
AU - Bastida-González, Fernando Guadalupe
AU - Zárate-Segura, Paola Berenice
AU - García-Mena, Jaime
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/12
Y1 - 2021/12
N2 - Objectives: COVID-19 is a viral transmissible disease and there is limited evidence on vertical transmission and prevalence of SARS-CoV-2 during pregnancy, birth, and the postnatal period. This descriptive cross-sectional study aimed to evaluate the possible perinatal transmission of SARS-CoV-2 in mothers and neonates in a Mexican population. Methods: A total of 133 nasopharyngeal swab samples from mothers, 131 swab samples from neonates, and 140 colostrum samples were obtained, and the presence of SARS-CoV-2 was determined by qPCR. Results: One in eight asymptomatic 38–39 weeks’ pregnant women were positive for the presence of SARS-CoV-2 in nasopharyngeal swabs taken just before delivery; and one in 12 nasopharyngeal swabs collected from neonates immediately after delivery without breast feeding were also positive. It was also determined that one in 47 colostrum/milk samples were positive for the test. In addition, there was no association between positive results and any collected metadata of mothers or newborns. Conclusions: Asymptomatic women carried the SARS-CoV-2 virus during delivery, with perinatal transmission of SARS-CoV-2 to newborns. Since neonates were sampled immediately after birth, the detection of positive cases might be due to infection by the virus in utero.
AB - Objectives: COVID-19 is a viral transmissible disease and there is limited evidence on vertical transmission and prevalence of SARS-CoV-2 during pregnancy, birth, and the postnatal period. This descriptive cross-sectional study aimed to evaluate the possible perinatal transmission of SARS-CoV-2 in mothers and neonates in a Mexican population. Methods: A total of 133 nasopharyngeal swab samples from mothers, 131 swab samples from neonates, and 140 colostrum samples were obtained, and the presence of SARS-CoV-2 was determined by qPCR. Results: One in eight asymptomatic 38–39 weeks’ pregnant women were positive for the presence of SARS-CoV-2 in nasopharyngeal swabs taken just before delivery; and one in 12 nasopharyngeal swabs collected from neonates immediately after delivery without breast feeding were also positive. It was also determined that one in 47 colostrum/milk samples were positive for the test. In addition, there was no association between positive results and any collected metadata of mothers or newborns. Conclusions: Asymptomatic women carried the SARS-CoV-2 virus during delivery, with perinatal transmission of SARS-CoV-2 to newborns. Since neonates were sampled immediately after birth, the detection of positive cases might be due to infection by the virus in utero.
KW - COVID-19
KW - Human milk
KW - Perinatal transmission
KW - RT-ddPCR
KW - RT-qPCR
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85118757718&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2021.10.006
DO - 10.1016/j.ijid.2021.10.006
M3 - Artículo
C2 - 34628021
AN - SCOPUS:85118757718
SN - 1201-9712
VL - 113
SP - 225
EP - 232
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
