TY - JOUR
T1 - Spirulina (Arthrospira) protects against cadmium-induced teratogenic damage in mice
AU - Paniagua-Castro, Norma
AU - Escalona-Cardoso, Gerardo
AU - Hernández-Navarro, Dolores
AU - Pérez-Pastén, Ricardo
AU - Chamorro-Cevallos, Germán
PY - 2011/4/1
Y1 - 2011/4/1
N2 - The role of Spirulina (Arthrospira) in preventing cadmium (Cd) teratogenicity in ICR mice was studied. Cd was administered intraperitoneally to female mice at 1.5mg/kg on gestation day (GD)-7, and Spirulina was given by peroral (intragastric) administration at 62.5, 125, 250, or 500mg/kg from GD-0 through GD-17 (the day when animals were sacrificed). Because among the mechanisms suggested to account for reproductive damage are oxidative stress and lipoperoxidation, embryonic hydroperoxides were also determined. Treatment with Spirulina at the three highest doses significantly decreased the frequency of fetuses with exencephaly, micrognathia, and skeletal abnormalities induced by Cd. Furthermore, Spirulina treatment significantly and dose-dependently decreased lipid peroxidation, which was dramatically increased by administration of the metal. The results of the present study clearly point to the therapeutic potential of Spirulina in Cd-induced teratogenicity and probably through its antioxidant activity.
AB - The role of Spirulina (Arthrospira) in preventing cadmium (Cd) teratogenicity in ICR mice was studied. Cd was administered intraperitoneally to female mice at 1.5mg/kg on gestation day (GD)-7, and Spirulina was given by peroral (intragastric) administration at 62.5, 125, 250, or 500mg/kg from GD-0 through GD-17 (the day when animals were sacrificed). Because among the mechanisms suggested to account for reproductive damage are oxidative stress and lipoperoxidation, embryonic hydroperoxides were also determined. Treatment with Spirulina at the three highest doses significantly decreased the frequency of fetuses with exencephaly, micrognathia, and skeletal abnormalities induced by Cd. Furthermore, Spirulina treatment significantly and dose-dependently decreased lipid peroxidation, which was dramatically increased by administration of the metal. The results of the present study clearly point to the therapeutic potential of Spirulina in Cd-induced teratogenicity and probably through its antioxidant activity.
KW - Spirulina
KW - antioxidant activity
KW - cadmium
KW - mice
KW - teratogenicity
UR - http://www.scopus.com/inward/record.url?scp=79953230531&partnerID=8YFLogxK
U2 - 10.1089/jmf.2010.0070
DO - 10.1089/jmf.2010.0070
M3 - Artículo
SN - 1096-620X
VL - 14
SP - 398
EP - 404
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
IS - 4
ER -