TY - JOUR
T1 - Siloxane-inorganic chemical crosslinking of hyaluronic acid – based hybrid hydrogels
T2 - Structural characterization
AU - Sánchez-Téllez, D. A.
AU - Rodríguez-Lorenzo, L. M.
AU - Téllez-Jurado, L.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2020/2/15
Y1 - 2020/2/15
N2 - HA-based hybrid hydrogels were successfully developed. The polysaccharide (HA) chains were chemically modified and hybridized via amidation of their carboxylic groups with aminosilane molecules. HA-polysaccharide chains were crosslinked by a 3D siloxane organic-inorganic matrix via sol-gel. The novel inorganic crosslinking network (PDMS-SiO2) provided to sodium hyaluronate (HA) strong chemical bonds, giving restriction to their natural hydrophilicity and stiffness to its structure (improved rheological properties). It was observed that synthesis conditions such as starting HA concentration solution and temperature determined gelling times, efficiency in the polysaccharide chemical modification and in crosslinking hydrolysis-condensation reactions, resulting in the siloxane organic-inorganic matrix. Drying processes influenced crosslinking in HA hybrid hydrogels, either by enhancing polycondensation reactions or inhibiting them. Room temperature-drying produced more densified hybrid structures. Freeze-drying increased porosity and surface hydroxyl groups (-OH) resulting in more Q3 structural units. 60 °C-drying boosted polycondensation of monodendate structural units, enhancing the formation of hybrid D-Q bonds.
AB - HA-based hybrid hydrogels were successfully developed. The polysaccharide (HA) chains were chemically modified and hybridized via amidation of their carboxylic groups with aminosilane molecules. HA-polysaccharide chains were crosslinked by a 3D siloxane organic-inorganic matrix via sol-gel. The novel inorganic crosslinking network (PDMS-SiO2) provided to sodium hyaluronate (HA) strong chemical bonds, giving restriction to their natural hydrophilicity and stiffness to its structure (improved rheological properties). It was observed that synthesis conditions such as starting HA concentration solution and temperature determined gelling times, efficiency in the polysaccharide chemical modification and in crosslinking hydrolysis-condensation reactions, resulting in the siloxane organic-inorganic matrix. Drying processes influenced crosslinking in HA hybrid hydrogels, either by enhancing polycondensation reactions or inhibiting them. Room temperature-drying produced more densified hybrid structures. Freeze-drying increased porosity and surface hydroxyl groups (-OH) resulting in more Q3 structural units. 60 °C-drying boosted polycondensation of monodendate structural units, enhancing the formation of hybrid D-Q bonds.
KW - Hybrids
KW - Inorganic chemical crosslinking
KW - Siloxane matrix
KW - Sodium hyaluronate
UR - http://www.scopus.com/inward/record.url?scp=85075503835&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2019.115590
DO - 10.1016/j.carbpol.2019.115590
M3 - Artículo
C2 - 31887936
AN - SCOPUS:85075503835
SN - 0144-8617
VL - 230
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 115590
ER -