TY - JOUR
T1 - Safety of a dual potential prebiotic system from Mexican agave "Metlin® and Metlos®", incorporated to an infant formula for term newborn babies
T2 - A randomized controlled trial
AU - López-Velázquez, Gabriel
AU - Díaz-García, Luisa
AU - Anzo, Anahi
AU - Parra-Ortiz, Minerva
AU - Llamosas-Gallardo, Beatriz
AU - Ortiz-Hernández, Ana Alejandra
AU - Mancilla-Ramírez, Javier
AU - Manuel Cruz-Rubio, José
AU - Gutiérrez-Castrellón, Pedro
PY - 2013
Y1 - 2013
N2 - Rationale. Infant formulae are being supplemented with probiotics, prebiotics, or symbiotic despite uncertainties regarding their efficacy. Mexican agave is an interesting source of fructans with particular features and with potential prebiotic effects. Material and methods. RCT in 600 healthy term babies (20 ± 7 days), allocated to receive standard infant formula (control) or infant formula added with a dual prebiotic system "Metlin® and Metlos®", from Mexican agave. Primary outcomes include stools frequency, stools consistency, gastrointestinal intolerance (frequency of abdominal distension, flatulency, regurgitations, vomiting). Secondary outcomes inelude changes on weight and height along the study and frequency of dermatologic problems (eczema). Results. In 66,120 days of total follow-up, there were no differences on the frequency of stools passage (Human Milk: 3.8 ± 2.4 evacuations per day; Pro + Metlin + Metlos 3.6 ± 2.0; Pro + Metlin 3.6 ± 2; only Pro 3.4 ± 2.3, only formula 3.4 ± 2.0; p NS). Consistency of stools was similar between human milk and prebiotics supplemented groups. Also the frequency of gastrointestinal symptoms was significantly low between these groups. Conclusions. Fructans derivate from agave and added to infant formula are safe and well tolerated by Mexican healthy term babies.
AB - Rationale. Infant formulae are being supplemented with probiotics, prebiotics, or symbiotic despite uncertainties regarding their efficacy. Mexican agave is an interesting source of fructans with particular features and with potential prebiotic effects. Material and methods. RCT in 600 healthy term babies (20 ± 7 days), allocated to receive standard infant formula (control) or infant formula added with a dual prebiotic system "Metlin® and Metlos®", from Mexican agave. Primary outcomes include stools frequency, stools consistency, gastrointestinal intolerance (frequency of abdominal distension, flatulency, regurgitations, vomiting). Secondary outcomes inelude changes on weight and height along the study and frequency of dermatologic problems (eczema). Results. In 66,120 days of total follow-up, there were no differences on the frequency of stools passage (Human Milk: 3.8 ± 2.4 evacuations per day; Pro + Metlin + Metlos 3.6 ± 2.0; Pro + Metlin 3.6 ± 2; only Pro 3.4 ± 2.3, only formula 3.4 ± 2.0; p NS). Consistency of stools was similar between human milk and prebiotics supplemented groups. Also the frequency of gastrointestinal symptoms was significantly low between these groups. Conclusions. Fructans derivate from agave and added to infant formula are safe and well tolerated by Mexican healthy term babies.
KW - Agave fructans safety
KW - Children
KW - Metlin and metlos
UR - http://www.scopus.com/inward/record.url?scp=84896750199&partnerID=8YFLogxK
M3 - Artículo
SN - 0034-8376
VL - 65
SP - 483
EP - 490
JO - Revista de Investigacion Clinica
JF - Revista de Investigacion Clinica
IS - 6
ER -