TY - JOUR
T1 - Role of the sympathetic and renin angiotensin systems in the glucose-induced increase of blood pressure in rats
AU - Villafaña, Santiago
AU - Huang, Fengyang
AU - Hong, Enrique
N1 - Funding Information:
This work is supported by grants 30750-M and 000489 from CONACYT. The authors thank Mr. J. Sánchez for technical assistance and Mr. Héctor Vázquez for his bibliographic help.
PY - 2004/12/15
Y1 - 2004/12/15
N2 - The pressor effect induced by acute hyperglycemia is not well understood, therefore, it was of interest to study the effect of intravenous glucose infusion on the mean arterial pressure of anesthetized Wistar rats. Animals received glucose (100 mg/kg/min, i.v.), mannitol or saline during 30 min, but only glucose increased the mean arterial pressure (about 40 mm Hg), plasma glucose, insulin and nitric oxide (NO). Pretreatment with reserpine or indorenate (a central antihypertensive) inhibited completely the pressor effect of glucose. Reserpine also decreased the plasma NO levels. Pretreatment with ramipril or with streptozotocin decreased the late phase of the glucose-induced pressor response and the NO levels, the latter treatment also abolishes insulin plasma concentrations. The present results suggest that the pressor effect induced by glucose has an early phase due to an increase of efferent sympathetic discharges and a delayed phase produced by the activation of the renin angiotensin system.
AB - The pressor effect induced by acute hyperglycemia is not well understood, therefore, it was of interest to study the effect of intravenous glucose infusion on the mean arterial pressure of anesthetized Wistar rats. Animals received glucose (100 mg/kg/min, i.v.), mannitol or saline during 30 min, but only glucose increased the mean arterial pressure (about 40 mm Hg), plasma glucose, insulin and nitric oxide (NO). Pretreatment with reserpine or indorenate (a central antihypertensive) inhibited completely the pressor effect of glucose. Reserpine also decreased the plasma NO levels. Pretreatment with ramipril or with streptozotocin decreased the late phase of the glucose-induced pressor response and the NO levels, the latter treatment also abolishes insulin plasma concentrations. The present results suggest that the pressor effect induced by glucose has an early phase due to an increase of efferent sympathetic discharges and a delayed phase produced by the activation of the renin angiotensin system.
KW - Blood pressure
KW - Glucose
KW - Insulin
KW - Renin angiotensin system
KW - Sympathetic nervous system
KW - Vasodilation
UR - http://www.scopus.com/inward/record.url?scp=9944220556&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2004.10.055
DO - 10.1016/j.ejphar.2004.10.055
M3 - Artículo
SN - 0014-2999
VL - 506
SP - 143
EP - 150
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -