TY - JOUR
T1 - Risperidone Ameliorates Prefrontal Cortex Neural Atrophy and Oxidative/Nitrosative Stress in Brain and Peripheral Blood of Rats with Neonatal Ventral Hippocampus Lesion
AU - Tendilla-Beltrán, Hiram
AU - Meneses-Prado, Silvia
AU - Vázquez-Roque, Rubén Antonio
AU - Tapia-Rodríguez, Miguel
AU - Vázquez-Hernández, Andrea Judith
AU - Coatl-Cuaya, Heriberto
AU - Martín-Hernández, David
AU - MacDowell, Karina S.
AU - Garcés-Ramírez, Linda
AU - Leza, Juan C.
AU - Flores, Gonzalo
N1 - Publisher Copyright:
Copyright © 2019 the authors
PY - 2019/10/23
Y1 - 2019/10/23
N2 - Reduction of the dendritic arbor length and the lack of dendritic spines in the pyramidal cells of the prefrontal cortex (PFC) are prevalent pathological features in schizophrenia (SZ). Neonatal ventral hippocampus lesion (NVHL) in male rats reproduces these neuronal characteristics and here we describe how this is a consequence of BDNF/TrkB pathway disruption. Moreover, COX-2 proinflammatory state, as well as Nrf-2 antioxidant impairment, triggers oxidative/nitrosative stress, which also contributes to dendritic spine impairments in the PFC. Interestingly, oxidative/nitrosative stress was also detected in the periphery of NVHL animals. Furthermore, risperidone treatment had a neurotrophic effect on the PFC and antioxidant effects on the brain and periphery of NVHL animals; these cellular effects were related to behavioral improvement. Our data highlight the link between brain development and immune response, as well as several other factors to understand mechanisms related to the pathophysiology of SZ.
AB - Reduction of the dendritic arbor length and the lack of dendritic spines in the pyramidal cells of the prefrontal cortex (PFC) are prevalent pathological features in schizophrenia (SZ). Neonatal ventral hippocampus lesion (NVHL) in male rats reproduces these neuronal characteristics and here we describe how this is a consequence of BDNF/TrkB pathway disruption. Moreover, COX-2 proinflammatory state, as well as Nrf-2 antioxidant impairment, triggers oxidative/nitrosative stress, which also contributes to dendritic spine impairments in the PFC. Interestingly, oxidative/nitrosative stress was also detected in the periphery of NVHL animals. Furthermore, risperidone treatment had a neurotrophic effect on the PFC and antioxidant effects on the brain and periphery of NVHL animals; these cellular effects were related to behavioral improvement. Our data highlight the link between brain development and immune response, as well as several other factors to understand mechanisms related to the pathophysiology of SZ.
KW - BDNF/TrkB pathway
KW - COX-2
KW - Neonatal ventral hippocampus lesion
KW - Oxidative/nitrosative stress
KW - Prefrontal cortex
KW - Risperidone
UR - http://www.scopus.com/inward/record.url?scp=85074117965&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.1249-19.2019
DO - 10.1523/JNEUROSCI.1249-19.2019
M3 - Artículo
C2 - 31519825
AN - SCOPUS:85074117965
SN - 0270-6474
VL - 39
SP - 8584
EP - 8599
JO - The Journal of neuroscience : the official journal of the Society for Neuroscience
JF - The Journal of neuroscience : the official journal of the Society for Neuroscience
IS - 43
ER -