TY - JOUR
T1 - Resveratrol
T2 - A natural compound with pharmacological potential in neurodegenerative diseases
AU - Rocha-González, Héctor I.
AU - Ambriz-Tututi, Mónica
AU - Granados-Soto, Vinicio
PY - 2008/9
Y1 - 2008/9
N2 - Resveratrol is a phytoalexin structurally related to stilbenes, which is synthesized in considerable amounts in the skin of grapes, raspberries, mulberries, pistachios and peanuts, and by at least 72 medicinal and edible plant species in response to stress conditions. It was isolated in 1940 and did not maintain much interest for around five decades until its role in treatment of cardiovascular diseases was suggested. To date, resveratrol has been identified as an agent that may be useful to treat cancer, pain, inflammation, tissue injury, and other diseases. However, currently the attention is being focused in analyzing its properties against neurodegenerative diseases and as antiaging compound. It has been reported that resveratrol shows effects in in vitro models of epilepsy, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and nerve injury. However, evidences in vivo as well as in human beings are still lacking. Thus, further investigations on the pharmacological effects of resveratrol in vivo are necessary before any conclusions on its effects on neurodegenerative diseases can be obtained.
AB - Resveratrol is a phytoalexin structurally related to stilbenes, which is synthesized in considerable amounts in the skin of grapes, raspberries, mulberries, pistachios and peanuts, and by at least 72 medicinal and edible plant species in response to stress conditions. It was isolated in 1940 and did not maintain much interest for around five decades until its role in treatment of cardiovascular diseases was suggested. To date, resveratrol has been identified as an agent that may be useful to treat cancer, pain, inflammation, tissue injury, and other diseases. However, currently the attention is being focused in analyzing its properties against neurodegenerative diseases and as antiaging compound. It has been reported that resveratrol shows effects in in vitro models of epilepsy, Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and nerve injury. However, evidences in vivo as well as in human beings are still lacking. Thus, further investigations on the pharmacological effects of resveratrol in vivo are necessary before any conclusions on its effects on neurodegenerative diseases can be obtained.
KW - Brain injury
KW - Clinical studies
KW - Lifespan
KW - Neurodegenerative diseases
KW - Neuropathic pain
KW - Pharmacokinetics
KW - Resveratrol
UR - http://www.scopus.com/inward/record.url?scp=49749083488&partnerID=8YFLogxK
U2 - 10.1111/j.1755-5949.2008.00045.x
DO - 10.1111/j.1755-5949.2008.00045.x
M3 - Artículo de revisión
C2 - 18684235
SN - 1755-5930
VL - 14
SP - 234
EP - 247
JO - CNS Neuroscience and Therapeutics
JF - CNS Neuroscience and Therapeutics
IS - 3
ER -