TY - JOUR
T1 - Repeated restraint stress reduces the number of IgA-producing cells in Peyer's patches
AU - Martínez-Carrillo, Beatriz Elina
AU - Godinez-Victoria, Marycarmen
AU - Jarillo-Luna, Adriana
AU - Oros-Pantoja, Rigoberto
AU - Abarca-Rojano, Edgar
AU - Rivera-Aguilar, Víctor
AU - Pacheco Yépez, Judith
AU - Sánchez-Torres, Luvia Enid
AU - Campos-Rodríguez, Rafael
PY - 2011/3
Y1 - 2011/3
N2 - The few reports that have analyzed the effects of stress on the immune cells of the intestinal mucosa or the functions of these cells have tended to focus on S-IgA levels in saliva, and these studies have shown contradictory results. The principal objective of this study was to analyze the effects of repeated restraint stress on the number and distribution of immune cells in Peyer's patches (PPs) as well as the effects of glucocorticoid and catecholamine administration on the same stress-related parameters. Upon analyzing the effect of repeated restraint stress on PPs, it was found that there was no modification in the morphological structure of the PPs but that restraint stress reduced the total number of lymphocytes and the number of CD8+ T cells, B cells, and plasma cells in PPs. Only at the site of PPs where IgA-producing plasma cells are most numerous (the dome) was a decrease found in this type of cell. These effects were due at least in part to the effect of glucocorticoids and catecholamines. Since IgA produced in PPs is a natural antibody that impedes bacterial infections, repeated stress may favor the entry of pathogens through the intestine.
AB - The few reports that have analyzed the effects of stress on the immune cells of the intestinal mucosa or the functions of these cells have tended to focus on S-IgA levels in saliva, and these studies have shown contradictory results. The principal objective of this study was to analyze the effects of repeated restraint stress on the number and distribution of immune cells in Peyer's patches (PPs) as well as the effects of glucocorticoid and catecholamine administration on the same stress-related parameters. Upon analyzing the effect of repeated restraint stress on PPs, it was found that there was no modification in the morphological structure of the PPs but that restraint stress reduced the total number of lymphocytes and the number of CD8+ T cells, B cells, and plasma cells in PPs. Only at the site of PPs where IgA-producing plasma cells are most numerous (the dome) was a decrease found in this type of cell. These effects were due at least in part to the effect of glucocorticoids and catecholamines. Since IgA produced in PPs is a natural antibody that impedes bacterial infections, repeated stress may favor the entry of pathogens through the intestine.
KW - Catecholamines
KW - Glucocorticoids
KW - IgA
KW - Peyer's patches
KW - Repeated restraint stress
UR - http://www.scopus.com/inward/record.url?scp=78650887483&partnerID=8YFLogxK
U2 - 10.1159/000322625
DO - 10.1159/000322625
M3 - Artículo
C2 - 21212701
SN - 1021-7401
VL - 18
SP - 131
EP - 141
JO - NeuroImmunoModulation
JF - NeuroImmunoModulation
IS - 3
ER -