TY - JOUR
T1 - Relaxant effects of Peperomia hispidula (Sw.) A. dietr. on isolated rat tracheal rings
AU - Arrieta, Jesús
AU - López-Lorenzo, Yaraset
AU - Gómez-Patiño, Mayra Beatriz
AU - Sánchez-Mendoza, Yolanda
AU - Sánchez-Mendoza, María Elena
PY - 2018/11/1
Y1 - 2018/11/1
N2 - © 2018, Universidad de Santiago de Chile. All rights reserved. Peperomia hispidula (Sw.) A. Dietr. is used in Mexican traditional medicine for treating respiratory illnesses such as asthma. The latter disorder results from an excessive and inappropriate constriction of airway smooth muscle. The aim of the present study was to evaluate the relaxant activity of P. hispidula on isolated rat tracheal rings contracted with carbachol. The methyleugenol was identified as the main active constituent in the dichloromethane extract. To explore the possible mechanism of action, concentration-response curves were constructed in the presence and absence of propranolol (3 μM), indomethacin (10 μM), glibenclamide (1 μM), and L-NAME (300 μM), finding that neither reduced methyleugenol-induced smooth muscle relaxation. In conclusion, P. hispidula herein displayed relaxant activity on rat tracheal rings. The effect of methyleugenol, was probably not related to the activation of β 2 -adrenoceptors, prostaglandins, K +ATP channels or nitric oxide.
AB - © 2018, Universidad de Santiago de Chile. All rights reserved. Peperomia hispidula (Sw.) A. Dietr. is used in Mexican traditional medicine for treating respiratory illnesses such as asthma. The latter disorder results from an excessive and inappropriate constriction of airway smooth muscle. The aim of the present study was to evaluate the relaxant activity of P. hispidula on isolated rat tracheal rings contracted with carbachol. The methyleugenol was identified as the main active constituent in the dichloromethane extract. To explore the possible mechanism of action, concentration-response curves were constructed in the presence and absence of propranolol (3 μM), indomethacin (10 μM), glibenclamide (1 μM), and L-NAME (300 μM), finding that neither reduced methyleugenol-induced smooth muscle relaxation. In conclusion, P. hispidula herein displayed relaxant activity on rat tracheal rings. The effect of methyleugenol, was probably not related to the activation of β 2 -adrenoceptors, prostaglandins, K +ATP channels or nitric oxide.
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M3 - Article
SN - 0717-7917
SP - 610
EP - 618
JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
JF - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
ER -