Relaxant and antispasmodic effect in isolated guinea pig ileum treated with extracts of Xylaria sp an endophytic fungus of the Mexican yew, Taxus globosa

Xylaria sp is known as endophytic microorganisms which grown in the Mexican yew, Taxus globosa schlec, that is the less known among the four native yews of the western hemishpere. The antispasmodic effect of hexane, chloroform and methanol extracts of Xylaria sp were studied in vitro on guinea pig ileum against three spasmogens, acetylcholine, histamine and barium chloride. The hexane extract produces a significant antispasmodic effect on the contractions of ileum induced by acetylcholine, histamine and barium chloride. The IC₅₀ for each was 7.81, 5.46 and 10.32 mg/mL respectively. These results show that hexane extract of Xylaria sp possesses both anticholinergic and antihistaminic properties.