TY - JOUR
T1 - Regioselective mercury(I)/palladium(II)-catalyzed single-step approach for the synthesis of imines and 2-substituted indoles
AU - Gutiérrez, Rsuini U.
AU - Hernández-Montes, Mayra
AU - Mendieta-Moctezuma, Aarón
AU - Delgado, Francisco
AU - Tamariz, Joaquín
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - An efficient synthesis of ketimines was achieved through a regioselective Hg(I)-catalyzed hydroamination of terminal acetylenes in the presence of anilines. The Pd(II)-catalyzed cycliza-tion of these imines into the 2-substituted indoles was satisfactorily carried out by a C-H acti-vation. In a single-step approach, a variety of 2-substituted indoles were also generated via a Hg(I)/Pd(II)-catalyzed, one-pot, two-step process, starting from anilines and terminal acetylenes. The arylacetylenes proved to be more effective than the alkyl derivatives.
AB - An efficient synthesis of ketimines was achieved through a regioselective Hg(I)-catalyzed hydroamination of terminal acetylenes in the presence of anilines. The Pd(II)-catalyzed cycliza-tion of these imines into the 2-substituted indoles was satisfactorily carried out by a C-H acti-vation. In a single-step approach, a variety of 2-substituted indoles were also generated via a Hg(I)/Pd(II)-catalyzed, one-pot, two-step process, starting from anilines and terminal acetylenes. The arylacetylenes proved to be more effective than the alkyl derivatives.
KW - Imines
KW - Mercury(I)-catalyzed alkyne hydroamination
KW - One-pot indole synthesis
KW - Pd-catalyzed oxidative cyclization
UR - http://www.scopus.com/inward/record.url?scp=85110387500&partnerID=8YFLogxK
U2 - 10.3390/molecules26134092
DO - 10.3390/molecules26134092
M3 - Artículo
C2 - 34279432
AN - SCOPUS:85110387500
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 13
M1 - 4092
ER -