Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay

Juan Castelán-Vega, Laura Corvette, Lev Sirota, Juan Arciniega

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge. Copyright © 2011, American Society for Microbiology. All Rights Reserved.
Original languageAmerican English
Pages (from-to)349-351
Number of pages3
JournalClinical and Vaccine Immunology
DOIs
StatePublished - 1 Feb 2011

Fingerprint

Dive into the research topics of 'Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay'. Together they form a unique fingerprint.

Cite this