Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay

Juan Castelán-Vega; Laura Corvette; Lev Sirota; Juan Arciniega

doi:10.1128/CVI.00267-10

Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay

Juan Castelán-Vega, Laura Corvette, Lev Sirota, Juan Arciniega

Escuela Nacional de Ciencias Biológicas (ENCB)

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

Original language	American English
Pages (from-to)	349-351
Number of pages	3
Journal	Clinical and Vaccine Immunology
DOIs	https://doi.org/10.1128/CVI.00267-10
State	Published - 1 Feb 2011

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abstract = "We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge. Copyright {\textcopyright} 2011, American Society for Microbiology. All Rights Reserved.",

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AB - We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge. Copyright © 2011, American Society for Microbiology. All Rights Reserved.

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Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay

Abstract

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