Reduction of immunogenicity of anthrax vaccines subjected to thermal stress, as measured by a toxin neutralization assay

Juan Castelán-Vega, Laura Corvette, Lev Sirota, Juan Arciniega

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    12 Scopus citations

    Abstract

    We report that a toxin neutralization assay (TNA) can detect a decrease in the immunogenicity of anthrax vaccines as a consequence of brief exposure to elevated temperature. This attribute of TNA may help in adopting immunogenicity as a replacement of the current potency test, which involves protection from lethal challenge.

    Original languageEnglish
    Pages (from-to)349-351
    Number of pages3
    JournalClinical and Vaccine Immunology
    Volume18
    Issue number2
    DOIs
    StatePublished - 1 Feb 2011

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