TY - JOUR
T1 - Recent advances in medicinal chemistry of sulfonamides. rational design as anti-tumoral, anti-bacterial and anti-inflammatory agents
AU - Shah, Syed Shoaib Ahmad
AU - Rivera, Gildardo
AU - Ashfaq, Muhammad
PY - 2013
Y1 - 2013
N2 - Now-a-days, cancer is becoming one of the major problems of public health in the world. Pharmacology treatment is a way to increase quality and long life. Predominantly, in last decade sulfonamide derivatives have been described as potential carbonic anhydrase inhibitors. In the present work, we describe recent advances during the last decade in medicinal chemistry of sulfonamides derivatives with some examples of rational design as anti-tumoral, antibacterial and anti-inflammatory agents. We show strategy design, structure-activity relationship, biological activity and advances of new sulfonamide compounds that have more health significance than some clinically used sulfonamides.
AB - Now-a-days, cancer is becoming one of the major problems of public health in the world. Pharmacology treatment is a way to increase quality and long life. Predominantly, in last decade sulfonamide derivatives have been described as potential carbonic anhydrase inhibitors. In the present work, we describe recent advances during the last decade in medicinal chemistry of sulfonamides derivatives with some examples of rational design as anti-tumoral, antibacterial and anti-inflammatory agents. We show strategy design, structure-activity relationship, biological activity and advances of new sulfonamide compounds that have more health significance than some clinically used sulfonamides.
KW - Anti-bacterial
KW - Anti-inflammatory
KW - Anti-tumoral
KW - Biological activity
KW - Clinical use
KW - Structure-activity relationship
KW - Sulfonamide
UR - http://www.scopus.com/inward/record.url?scp=84875021547&partnerID=8YFLogxK
U2 - 10.2174/138955713804484749
DO - 10.2174/138955713804484749
M3 - Artículo
SN - 1389-5575
VL - 13
SP - 70
EP - 86
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 1
ER -