TY - JOUR
T1 - Rapid synthesis of (±)-r-7-benzyloxymethyl-cyclopenta-cis-[4,5][1,3]-oxazolo[3,2-a] pyrimidinones versatile carbocyclic nucleoside precursors
AU - Pérez, Nury
AU - Gordillo, Barbara
N1 - Funding Information:
This work was supported by CONACYT (Mexico) Grant 32221-E. N. P. is thankful to CONACYT for the fellowship granted for PhD studies. We are indebt to M. Salas-Reyes for the X-ray crystallographic study of compound 9 .
PY - 2003/1/27
Y1 - 2003/1/27
N2 - (±)-r-7-Benzyloxymethyl-cyclopenta-cis-[4,5][1,3]-oxazolo[3,2-a] pyrimidinones were synthesized in two steps from 1-hydroxymethyl-3-cyclopentene. These compounds are versatile intermediates for the synthesis of carbocyclic nucleosides. The synthesis has been accomplished by the iodofunctionalization of olefins as a method of coupling the pyrimidine bases and the carbocycle.
AB - (±)-r-7-Benzyloxymethyl-cyclopenta-cis-[4,5][1,3]-oxazolo[3,2-a] pyrimidinones were synthesized in two steps from 1-hydroxymethyl-3-cyclopentene. These compounds are versatile intermediates for the synthesis of carbocyclic nucleosides. The synthesis has been accomplished by the iodofunctionalization of olefins as a method of coupling the pyrimidine bases and the carbocycle.
KW - Carbocyclic nucleosides
KW - Cyclopenta-oxazolo pyrimidinones
KW - Iodofunctionalization
UR - http://www.scopus.com/inward/record.url?scp=0037467696&partnerID=8YFLogxK
U2 - 10.1016/S0040-4020(02)01531-4
DO - 10.1016/S0040-4020(02)01531-4
M3 - Artículo
SN - 0040-4020
VL - 59
SP - 671
EP - 676
JO - Tetrahedron
JF - Tetrahedron
IS - 5
ER -