TY - JOUR
T1 - Profilinas
T2 - Alergenos con relevancia clínica
AU - Landa-Pineda, César Manuel
AU - Guidos-Fogelbach, Guillermo
AU - Marchat-Marchau, Laurence
AU - López-Hidalgo, Marisol
AU - Arroyo-Becerra, Analilia
AU - Reyes-López, César Augusto Sandino
PY - 2013
Y1 - 2013
N2 - Introduction: Profilins are small ubiquitous proteins of 12-19 kDa involved in actin dynamics. These proteins are found in all eukaryotic organisms studied to date. Profilins have aminoacid sequences and tridimensional structure highly conserved. Allergic patients to pollen frequently have symptoms of allergy when ingestion of plant-derived foods like fruits, vegetables, seeds, among others. This phenomenon is known as latex-pollen-fruit allergy and it's the main cause of oral allergy syndrome (OAS) which is attributed to the cross-reactivity. Allergens shared between different sources theses are called panallergens for example are profilins which representing at least 20% of all pollen allergic patients. This cross-reactivity is results from the high amino acid sequence identity of profilin from plants, which is between 70% and 85%, this may explain the exacerbation symptoms of allergic patients to profilins from plants. Objectives: We described some characteristics which show us the important participation of the profilins in the sensitization of people allergic, especially to plants, fruits and pollen. Methods: We looked research aminoacid sequences of all allergenic profilins reported to date and these were analyzed. Conclusions: Profilins are important allergens that are underrated in clinical practice and contribute to cross-reactivity in sensitized individuals by profilins from other sources.
AB - Introduction: Profilins are small ubiquitous proteins of 12-19 kDa involved in actin dynamics. These proteins are found in all eukaryotic organisms studied to date. Profilins have aminoacid sequences and tridimensional structure highly conserved. Allergic patients to pollen frequently have symptoms of allergy when ingestion of plant-derived foods like fruits, vegetables, seeds, among others. This phenomenon is known as latex-pollen-fruit allergy and it's the main cause of oral allergy syndrome (OAS) which is attributed to the cross-reactivity. Allergens shared between different sources theses are called panallergens for example are profilins which representing at least 20% of all pollen allergic patients. This cross-reactivity is results from the high amino acid sequence identity of profilin from plants, which is between 70% and 85%, this may explain the exacerbation symptoms of allergic patients to profilins from plants. Objectives: We described some characteristics which show us the important participation of the profilins in the sensitization of people allergic, especially to plants, fruits and pollen. Methods: We looked research aminoacid sequences of all allergenic profilins reported to date and these were analyzed. Conclusions: Profilins are important allergens that are underrated in clinical practice and contribute to cross-reactivity in sensitized individuals by profilins from other sources.
KW - Allergen
KW - Cross-reactivity
KW - Oral allergy syndrome
KW - Panallergen
KW - Profilin
UR - http://www.scopus.com/inward/record.url?scp=84891781521&partnerID=8YFLogxK
M3 - Artículo de revisión
SN - 0002-5151
VL - 60
SP - 129
EP - 143
JO - Revista Alergia Mexico
JF - Revista Alergia Mexico
IS - 3
ER -