Production of IL-10, TNF and IL-12 by Peripheral Blood Mononuclear Cells in Mexican Workers Exposed to a Mixture of Benzene-Toluene-Xylene

Luis Cuauhtémoc Haro-García, Cuauhtémoc Arturo Juárez-Pérez, Guadalupe Aguilar-Madrid, Nadia Mayola Vélez-Zamora, Sergio Muñoz-Navarro, Rommel Chacón-Salinas, César Raúl González-Bonilla, Claudia Rosa Iturbe-Haro, Iris Estrada-García, Víctor Hugo Borja-Aburto

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Abstract

Background and Aims: Occupational exposure to low-level benzene and the joint action of toluene-xylene probably cause effects on circulating monocytes immune response. We undertook this study to determine relationship between occupational exposure to benzene-toluene-xylene mixture (BTX) and IL-10, TNF and IL-12 production by peripheral blood mononuclear cells. Methods: Exposure was estimated in 54 workers from a paint company in Mexico City through BTX . accumulated potential dose (BTX-APD). Two exposure groups were formed: high and low BTX-APD established with a cutoff point at ≥1.0 of BTX-APD, as a function of the geometric mean of the estimator's value distribution and the higher agreement between BTX-APD ≥1.0 and the areas referred as using (or not) organic solvents in the work process. IL-10, TNF and IL-12 concentrations were measured with ELISA. Through multiple linear regression models, the production of each of the proposed cytokines and of the whole set was assessed. Results: Workers with high BTX-APD showed a significant reduction in TNF production (β = -1,196.0 pg/mL; . p = 0.01); a reduction for IL-10 (β = -520.3; . p = 0.13) and IL-12 (β = -843.3; . p = 0.09) was also observed, although without statistical significance. Conclusions: TNF production assessed in workers with a high BTX-APD is lower than in those with a low BTX-APD, but not in IL-10 and IL-12 production. © 2012 IMSS.
Original languageAmerican English
Pages (from-to)51-57
Number of pages45
JournalArchives of Medical Research
DOIs
StatePublished - 1 Jan 2012

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    Haro-García, L. C., Juárez-Pérez, C. A., Aguilar-Madrid, G., Vélez-Zamora, N. M., Muñoz-Navarro, S., Chacón-Salinas, R., González-Bonilla, C. R., Iturbe-Haro, C. R., Estrada-García, I., & Borja-Aburto, V. H. (2012). Production of IL-10, TNF and IL-12 by Peripheral Blood Mononuclear Cells in Mexican Workers Exposed to a Mixture of Benzene-Toluene-Xylene. Archives of Medical Research, 51-57. https://doi.org/10.1016/j.arcmed.2012.01.008