TY - JOUR
T1 - Preparation of covalently bonded silica-alginate hybrid hydrogels by SCHIFF base and sol-gel reactions
AU - Hernández-González, Aurora C.
AU - Téllez-Jurado, Lucía
AU - Rodríguez-Lorenzo, Luis M.
N1 - Publisher Copyright:
© 2021 The Author(s)
PY - 2021/9/1
Y1 - 2021/9/1
N2 - Organic-inorganic hybrid materials overcome drawbacks associated with alginate hydrogels. In this work, covalently coupled silica-alginate hybrids were prepared by Schiff base formation and sol-gel reaction using alginate dialdehyde (ADA), (3-Aminopropyl) triethoxysilane (APTES), and APTES/tetraethylorthosilicate (TEOS) precursors. The influence of the polysaccharide/inorganic ratio, the nature of the inorganic precursor and the ionic crosslinking ability are studied. Prepared hybrids were characterized by FT-IR, 13C and 29Si NMR spectroscopies, SEM, and rheology. For ADA/APTES hybrids, at higher ADA content, Schiff base formation is predominant, but at lower ADA content, the sol-gel reaction is prevalent. However, the progress of the sol-gel reactions for ADA/(APTES+TEOS), is favored with higher ADA compositions. Introducing a posterior ionic crosslinking treatment was possible, increasing the moduli in ADA/(APTES+TEOS) hybrids from 86,207 Pa for 1.5 ADA/Si to 362,171 Pa for 1.5 ADA/Si-Ca. In-situ ADA-Silica hybrid hydrogels containing both ionic and covalent crosslinking can be successfully synthesized with the proposed method. CARBPOL-D-21-01042.
AB - Organic-inorganic hybrid materials overcome drawbacks associated with alginate hydrogels. In this work, covalently coupled silica-alginate hybrids were prepared by Schiff base formation and sol-gel reaction using alginate dialdehyde (ADA), (3-Aminopropyl) triethoxysilane (APTES), and APTES/tetraethylorthosilicate (TEOS) precursors. The influence of the polysaccharide/inorganic ratio, the nature of the inorganic precursor and the ionic crosslinking ability are studied. Prepared hybrids were characterized by FT-IR, 13C and 29Si NMR spectroscopies, SEM, and rheology. For ADA/APTES hybrids, at higher ADA content, Schiff base formation is predominant, but at lower ADA content, the sol-gel reaction is prevalent. However, the progress of the sol-gel reactions for ADA/(APTES+TEOS), is favored with higher ADA compositions. Introducing a posterior ionic crosslinking treatment was possible, increasing the moduli in ADA/(APTES+TEOS) hybrids from 86,207 Pa for 1.5 ADA/Si to 362,171 Pa for 1.5 ADA/Si-Ca. In-situ ADA-Silica hybrid hydrogels containing both ionic and covalent crosslinking can be successfully synthesized with the proposed method. CARBPOL-D-21-01042.
KW - Alginate dialdehyde
KW - Schiff base
KW - Silica-alginate hybrids
KW - Sol-gel process
KW - Synthesis parameters
UR - http://www.scopus.com/inward/record.url?scp=85106362788&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2021.118186
DO - 10.1016/j.carbpol.2021.118186
M3 - Artículo
C2 - 34119154
AN - SCOPUS:85106362788
SN - 0144-8617
VL - 267
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 118186
ER -