Preparation, bioactivity, and cytotoxicity studies of poly(ester urethane)s/SiO<inf>2</inf> nanocomposites

Rodrigo Jiménez-Gallegos, Luis M. Rodríguez-Lorenzo, Julio San Roman, Lucía Téllez-Jurado

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

© The Author(s) 2017. Degradable poly(ester urethane)s (PEUS)/nanosilica composites are prepared, and a preliminary evaluation of their potential to be used in calcified tissue regeneration is performed. First, poly(ethylene glycol succinate) (PEGS) of different molecular weights is prepared and then a prepolymer with an excess of 1,6-hexamethylene diisocyanate is synthesized; this prepolymer is subsequently extended with 1,4-butanediol in the presence of nanosilica particles. The effects of the structures of PEGS and PEUS are studied by means of attenuated total reflectance infrared, gel permeation chromatography, X-ray diffraction, thermogravimetric analysis, optical microscopy, and scanning electron microscopy. The materials show that similar crystalline structure independently of the molecular weight, however, increases the thermal resistance with higher molecular weight of nanocomposites. After soaking in simulated body fluid, the appearance of apatite phosphate bands in Fourier transformed infrared spectra suggests the bioactive character of these composites. In addition, degradation and toxicity test are performed. The materials are degradable but not cytotoxic after 7 days of testing.
Original languageAmerican English
Pages (from-to)108-122
Number of pages95
JournalJournal of Thermoplastic Composite Materials
DOIs
StatePublished - 1 Jan 2019
Externally publishedYes

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urethanes
Cytotoxicity
Bioactivity
prepolymers
esters
molecular weight
Nanocomposites
Esters
nanocomposites
Molecular weight
Succinic Acid
preparation
Polyethylene glycols
glycols
ethylene
Infrared radiation
diisocyanates
Apatites
Tissue regeneration
gel chromatography

Cite this

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abstract = "{\circledC} The Author(s) 2017. Degradable poly(ester urethane)s (PEUS)/nanosilica composites are prepared, and a preliminary evaluation of their potential to be used in calcified tissue regeneration is performed. First, poly(ethylene glycol succinate) (PEGS) of different molecular weights is prepared and then a prepolymer with an excess of 1,6-hexamethylene diisocyanate is synthesized; this prepolymer is subsequently extended with 1,4-butanediol in the presence of nanosilica particles. The effects of the structures of PEGS and PEUS are studied by means of attenuated total reflectance infrared, gel permeation chromatography, X-ray diffraction, thermogravimetric analysis, optical microscopy, and scanning electron microscopy. The materials show that similar crystalline structure independently of the molecular weight, however, increases the thermal resistance with higher molecular weight of nanocomposites. After soaking in simulated body fluid, the appearance of apatite phosphate bands in Fourier transformed infrared spectra suggests the bioactive character of these composites. In addition, degradation and toxicity test are performed. The materials are degradable but not cytotoxic after 7 days of testing.",
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Preparation, bioactivity, and cytotoxicity studies of poly(ester urethane)s/SiO<inf>2</inf> nanocomposites. / Jiménez-Gallegos, Rodrigo; Rodríguez-Lorenzo, Luis M.; San Roman, Julio; Téllez-Jurado, Lucía.

In: Journal of Thermoplastic Composite Materials, 01.01.2019, p. 108-122.

Research output: Contribution to journalArticle

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