TY - JOUR
T1 - Preclinical Biokinetic Modelling of Tc-99m Radiophamaceuticals Obtained from Semi-Automatic Image Processing
AU - Cornejo-Aragón, Luz G.
AU - Santos-Cuevas, Clara L.
AU - Ocampo-García, Blanca E.
AU - Chairez-Oria, Isaac
AU - Diaz-Nieto, Lorenza
AU - García-Quiroz, Janice
N1 - Publisher Copyright:
© 2017, Taiwanese Society of Biomedical Engineering.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - The aim of this study was to develop a semi automatic image processing algorithm (AIPA) based on the simultaneous information provided by X-ray and radioisotopic images to determine the biokinetic models of Tc-99m radiopharmaceuticals from quantification of image radiation activity in murine models. These radioisotopic images were obtained by a CCD (charge couple device) camera coupled to an ultrathin phosphorous screen in a preclinical multimodal imaging system (Xtreme, Bruker). The AIPA consisted of different image processing methods for background, scattering and attenuation correction on the activity quantification. A set of parametric identification algorithms was used to obtain the biokinetic models that characterize the interaction between different tissues and the radiopharmaceuticals considered in the study. The set of biokinetic models corresponded to the Tc-99m biodistribution observed in different ex vivo studies. This fact confirmed the contribution of the semi-automatic image processing technique developed in this study.
AB - The aim of this study was to develop a semi automatic image processing algorithm (AIPA) based on the simultaneous information provided by X-ray and radioisotopic images to determine the biokinetic models of Tc-99m radiopharmaceuticals from quantification of image radiation activity in murine models. These radioisotopic images were obtained by a CCD (charge couple device) camera coupled to an ultrathin phosphorous screen in a preclinical multimodal imaging system (Xtreme, Bruker). The AIPA consisted of different image processing methods for background, scattering and attenuation correction on the activity quantification. A set of parametric identification algorithms was used to obtain the biokinetic models that characterize the interaction between different tissues and the radiopharmaceuticals considered in the study. The set of biokinetic models corresponded to the Tc-99m biodistribution observed in different ex vivo studies. This fact confirmed the contribution of the semi-automatic image processing technique developed in this study.
KW - Biokinetic modelling
KW - Medical and biological imaging
KW - Radioisotopic image processing
KW - Tc-99m radiopharmaceuticals
UR - http://www.scopus.com/inward/record.url?scp=85037031928&partnerID=8YFLogxK
U2 - 10.1007/s40846-017-0250-4
DO - 10.1007/s40846-017-0250-4
M3 - Artículo
C2 - 29541015
SN - 1609-0985
VL - 37
SP - 887
EP - 898
JO - Journal of Medical and Biological Engineering
JF - Journal of Medical and Biological Engineering
IS - 6
ER -