TY - JOUR
T1 - Practical and high stereoselective synthesis of 3-(arylmethylene) isoindolin-1-ones from 2-formylbenzoic acid
AU - Reyes-González, Miguel Angel
AU - Zamudio-Medina, Angel
AU - Ordóñez, Mario
N1 - Funding Information:
The authors thank the CONACYT of Mexico, for financial support via project (62271). We thank to V. Labastida-Galván and S. Lagunas-Rivera for their technical assistance. One of us, MGX also thank the CONACYT for Graduate Scholarships.
PY - 2012/10/24
Y1 - 2012/10/24
N2 - Practical and high stereoselective synthesis of 3-(arylmethylene) isoindolin-1-ones is reported. The synthetic method involves the preparation of dimethyl isoindolin-1-one-3-yl-phosphonates by a 'one-pot' three-component reaction of 2-formylbenzoic acid with 4-methoxybenzylamine or aminoacetaldehyde dimethyl acetal and dimethyl phosphite under solvent and catalyst free-conditions, followed by a Horner reaction with several aryl aldehydes.
AB - Practical and high stereoselective synthesis of 3-(arylmethylene) isoindolin-1-ones is reported. The synthetic method involves the preparation of dimethyl isoindolin-1-one-3-yl-phosphonates by a 'one-pot' three-component reaction of 2-formylbenzoic acid with 4-methoxybenzylamine or aminoacetaldehyde dimethyl acetal and dimethyl phosphite under solvent and catalyst free-conditions, followed by a Horner reaction with several aryl aldehydes.
KW - 2-Formylbenzoic acid
KW - 3-Methyleneisoindolin-1-ones
KW - Aminophosphonates
KW - Horner reaction
KW - One-pot three-component reaction
UR - http://www.scopus.com/inward/record.url?scp=84866405361&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2012.08.040
DO - 10.1016/j.tetlet.2012.08.040
M3 - Artículo
AN - SCOPUS:84866405361
SN - 0040-4039
VL - 53
SP - 5756
EP - 5758
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 43
ER -