TY - JOUR
T1 - Potentiation of the Analgesic Effect of Tolmetin, a Potent Non‐steroidal Anti‐inflammatory Drug, by Caffeine in the Rat
AU - FLORES‐ACEVEDO, D. M.
AU - FLORES‐MURRIETA, F. J.
AU - CASTAÑEDA‐HERNÁNDEZ, G.
AU - LÓPEZ‐MUÑOZ, F. J.
PY - 1995/9
Y1 - 1995/9
N2 - The analgesic activities of tolmetin (0, 3, 10 and 32 mg kg−1), caffeine (0, 10, 18, 32 and 56 mg kg−1) and combinations of these doses were studied in the pain‐induced functional impairment model in the rat. Tolmetin was able to produce a dose‐dependent analgesic effect, whereas caffeine was ineffective in this model; 3–32, 3–56 and 10–56 mg kg−1 tolmetin‐caffeine, but not other combinations, yielded analgesic effects which were significantly greater than those observed with tolmetin alone. However, tolmetin pharmacokinetics were not modified by caffeine co‐administration. The results show that caffeine is able to potentiate the analgesic activity of tolmetin, probably by a pharmacodynamic mechanism of action, but only at selected dose combinations. 1995 Royal Pharmaceutical Society of Great Britain
AB - The analgesic activities of tolmetin (0, 3, 10 and 32 mg kg−1), caffeine (0, 10, 18, 32 and 56 mg kg−1) and combinations of these doses were studied in the pain‐induced functional impairment model in the rat. Tolmetin was able to produce a dose‐dependent analgesic effect, whereas caffeine was ineffective in this model; 3–32, 3–56 and 10–56 mg kg−1 tolmetin‐caffeine, but not other combinations, yielded analgesic effects which were significantly greater than those observed with tolmetin alone. However, tolmetin pharmacokinetics were not modified by caffeine co‐administration. The results show that caffeine is able to potentiate the analgesic activity of tolmetin, probably by a pharmacodynamic mechanism of action, but only at selected dose combinations. 1995 Royal Pharmaceutical Society of Great Britain
UR - http://www.scopus.com/inward/record.url?scp=84988169996&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.1995.tb00460.x
DO - 10.1111/j.2042-7158.1995.tb00460.x
M3 - Artículo
SN - 1460-8081
VL - 1
SP - 441
EP - 444
JO - Pharmacy and Pharmacology Communications
JF - Pharmacy and Pharmacology Communications
IS - 9
ER -