TY - JOUR
T1 - Polyphenols as potential enhancers of stem cell therapy against neurodegeneration
AU - Rodríguez-Vera, Diana
AU - Abad-García, Antonio
AU - Vargas-Mendoza, Nancy
AU - Pinto-Almazán, Rodolfo
AU - Farfán-García, Eunice D.
AU - Morales-González, José A.
AU - Soriano-Ursúa, Marvin A.
N1 - Publisher Copyright:
© 2021 Wolters Kluwer Medknow Publications. All rights reserved.
PY - 2022/10
Y1 - 2022/10
N2 - The potential of polyphenols for treating chronic-degenerative diseases (particularly neurodegenerative diseases) is attractive. However, the selection of the best polyphenol for each treatment, the mechanisms by which they act, and their efficacy are frequently discussed. In this review, the basics and the advances in the field, as well as suggestions for using natural and synthetic polyphenols alone or in a combinatorial strategy with stem cell assays, are compiled and discussed. Thus, stem cells exhibit several responses when polyphenols are added to their environment, which could provide us with knowledge for advancing the elucidation of the origin of neurodegeneration. But also, polyphenols are being included in the innovative strategies of novel therapies for treating neurodegenerative diseases as well as metabolic diseases related to neurodegeneration. In this regard, flavonoid compounds are suggested as the best natural polyphenols due to their several mechanisms for acting in ameliorative effects; but increasing reports are involving other polyphenols. Even if some facts limiting bioactivity prevent them from conventional use, some natural polyphenols and derivatives hold the promise for being improved compounds, judged by their induced effects. The current results suggest polyphenols as enhancers of stem cell therapy against the targeted diseases.
AB - The potential of polyphenols for treating chronic-degenerative diseases (particularly neurodegenerative diseases) is attractive. However, the selection of the best polyphenol for each treatment, the mechanisms by which they act, and their efficacy are frequently discussed. In this review, the basics and the advances in the field, as well as suggestions for using natural and synthetic polyphenols alone or in a combinatorial strategy with stem cell assays, are compiled and discussed. Thus, stem cells exhibit several responses when polyphenols are added to their environment, which could provide us with knowledge for advancing the elucidation of the origin of neurodegeneration. But also, polyphenols are being included in the innovative strategies of novel therapies for treating neurodegenerative diseases as well as metabolic diseases related to neurodegeneration. In this regard, flavonoid compounds are suggested as the best natural polyphenols due to their several mechanisms for acting in ameliorative effects; but increasing reports are involving other polyphenols. Even if some facts limiting bioactivity prevent them from conventional use, some natural polyphenols and derivatives hold the promise for being improved compounds, judged by their induced effects. The current results suggest polyphenols as enhancers of stem cell therapy against the targeted diseases.
KW - Alzheimer’s disease
KW - Parkinson’s disease
KW - chronic degenerative diseases
KW - combinatorial therapy
KW - metabolism
KW - neurodegenerative diseases
KW - neuronal damage
KW - neuroprotection
KW - polyphenols
KW - stem cell assays
UR - http://www.scopus.com/inward/record.url?scp=85139827731&partnerID=8YFLogxK
U2 - 10.4103/1673-5374.335826
DO - 10.4103/1673-5374.335826
M3 - Artículo de revisión
C2 - 35259814
SN - 1673-5374
VL - 17
SP - 2093
EP - 2101
JO - Neural Regeneration Research
JF - Neural Regeneration Research
IS - 10
ER -