Platelet glycoprotein IIIA PIA2 polymorphism is associated with ST elevation acute myocardial infarction in young Mexican population

David Santiago-Germán, Alfredo Leaños-Miranda, Ethel García-Latorre, Gabriela Borrayo-Sánchez, Abraham Majluf-Cruz, Irma Isordia-Salas

Research output: Contribution to journalArticle

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Abstract

Platelet membrane glycoprotein IIb/IIIa plays an important role in adhesion and platelet aggregation. Polymorphisms of genes in platelet activation and fibrinolysis have been associated with myocardial infarction (MI), however this has not been confirmed by others, and results are still controversial. The aim of this study was to determine the frequency distribution and association of polymorphism in the platelet glycoprotein GPIIIa PLA/A2 and the possible interaction with the 4G/5G in the plasminogen activator inhibitor genes with ST elevation acute myocardial infarction (STEAMI) in young Mexican subjects. A total of 254 unrelated patients with first STEAMI B45 years of age, who were admitted to a cardiovascular intense care unit and 254 healthy controls matched by age and gender were recruited from January 2006 and May 2011. The PIA1/A2 and 4G/5G polymorphism were determined in all participants by a PCR restriction based restriction endonuclease digestion. There was a difference in the PIA2 allele distribution between both groups (P = 0.001). Also, we found an increased percent of 4G allele in the group of patients compared to control group (P = 0.001). There was an increased risk for STEAMI in carries with the allele PIA2 and 4G (OR = 4.3, CI 95 % 1.7-6.5). The modifiable risk factors such: smoking, hypertension, family history of cardiovascular disease, and dyslipidemia were associated with myocardial infarction. This is the first study to evaluate the role of gene polymorphism in both the thrombotic and fibrinolytic pathways in young Mexican individuals with STEAMI and suggest a synergistic effect between PIA2 and 4G allele. © Springer Science+Business Media, LLC 2012.
Original languageAmerican English
Pages (from-to)389-396
Number of pages349
JournalJournal of Thrombosis and Thrombolysis
DOIs
StatePublished - 1 May 2012

Fingerprint

Platelet Membrane Glycoproteins
Alleles
Integrin beta3
varespladib methyl
Population
Myocardial Infarction
Platelet Membrane Glycoprotein IIb
Genes
Plasminogen Inactivators
Platelet Glycoprotein GPIIb-IIIa Complex
DNA Restriction Enzymes
Platelet Activation
Fibrinolysis
Dyslipidemias
Platelet Aggregation
Digestion
Cardiovascular Diseases
Smoking
Hypertension
Polymerase Chain Reaction

Cite this

Santiago-Germán, David ; Leaños-Miranda, Alfredo ; García-Latorre, Ethel ; Borrayo-Sánchez, Gabriela ; Majluf-Cruz, Abraham ; Isordia-Salas, Irma. / Platelet glycoprotein IIIA PIA2 polymorphism is associated with ST elevation acute myocardial infarction in young Mexican population. In: Journal of Thrombosis and Thrombolysis. 2012 ; pp. 389-396.
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abstract = "Platelet membrane glycoprotein IIb/IIIa plays an important role in adhesion and platelet aggregation. Polymorphisms of genes in platelet activation and fibrinolysis have been associated with myocardial infarction (MI), however this has not been confirmed by others, and results are still controversial. The aim of this study was to determine the frequency distribution and association of polymorphism in the platelet glycoprotein GPIIIa PLA/A2 and the possible interaction with the 4G/5G in the plasminogen activator inhibitor genes with ST elevation acute myocardial infarction (STEAMI) in young Mexican subjects. A total of 254 unrelated patients with first STEAMI B45 years of age, who were admitted to a cardiovascular intense care unit and 254 healthy controls matched by age and gender were recruited from January 2006 and May 2011. The PIA1/A2 and 4G/5G polymorphism were determined in all participants by a PCR restriction based restriction endonuclease digestion. There was a difference in the PIA2 allele distribution between both groups (P = 0.001). Also, we found an increased percent of 4G allele in the group of patients compared to control group (P = 0.001). There was an increased risk for STEAMI in carries with the allele PIA2 and 4G (OR = 4.3, CI 95 {\%} 1.7-6.5). The modifiable risk factors such: smoking, hypertension, family history of cardiovascular disease, and dyslipidemia were associated with myocardial infarction. This is the first study to evaluate the role of gene polymorphism in both the thrombotic and fibrinolytic pathways in young Mexican individuals with STEAMI and suggest a synergistic effect between PIA2 and 4G allele. {\circledC} Springer Science+Business Media, LLC 2012.",
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Platelet glycoprotein IIIA PIA2 polymorphism is associated with ST elevation acute myocardial infarction in young Mexican population. / Santiago-Germán, David; Leaños-Miranda, Alfredo; García-Latorre, Ethel; Borrayo-Sánchez, Gabriela; Majluf-Cruz, Abraham; Isordia-Salas, Irma.

In: Journal of Thrombosis and Thrombolysis, 01.05.2012, p. 389-396.

Research output: Contribution to journalArticle

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