Phytochemical composition and pharmacological evaluation of different extracts of Oenothera rosea L´Hér. ex Ait (Onagraceae) aerial part

Y. K. Márquez-Flores, M. E. Meléndez-Camargo, N. J. García-Mateos, M. C. Huerta-Anaya, S. S. Pablo-Pérez, R. Silva-Torres

Research output: Contribution to journalArticle

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Abstract

© 2018 South African Association of Botanists Oenothera genus consists of 145 herbs species which has been used for the treatment of skin diseases, diabetes mellitus, renal and liver problems, and as anti-diarrheic and anti-inflammatory drugs, among others. A great variety of chemical compounds have been reported from Oenothera genus among them tannins, flavonoids, steroids, carbohydrates and lipids. This study was focused on investigating the effect of different extracts of Oenothera rosea L´ Hér. ex Ait aerial part (from water ethanol, methanol, ethyl acetate, chloroform and hexane) on total flavonoid and phenolic compounds content; as well as the evaluation of their antioxidant, analgesic and anti-inflammatory activities. Antioxidant activity was performed considering the ability of the extracts to scavenge DPPH• free radicals, while analgesic and anti-inflammatory activities of most potent extracts were evaluated by acetic acid writhing reflex, hot plate and cotton pellet-induced granuloma formation models, respectively. Methanol, ethanol and ethyl acetate extracts showed a high phenolic compounds content, being ethanol the best solvent for extraction of flavonoids (28.84 ± 0.46 mg flavonoids/g extract). The highest antioxidant activity was observed with methanol, hexane and ethyl acetate extracts (89.51 ± 0.38, 89.42 ± 0.42 and 89.05 ± 0.34%, respectively). Ethanol and ethyl acetate extracts showed analgesic activity with inhibition percentages of the evaluated parameters of more than 50%. Ethyl acetate extract down-regulated chronic inflammation without inducing gastrointestinal damage. These findings provide scientific evidence of O. rosea folkloric use and highlight their importance as a possible natural treatment for several diseases.
Original languageAmerican English
Pages (from-to)245-250
Number of pages219
JournalSouth African Journal of Botany
DOIs
StatePublished - 1 May 2018

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Onagraceae
Oenothera
phytopharmaceuticals
aerial parts
acetates
antioxidants
ethyl alcohol
evaluation
extracts
methyl alcohol
flavonoids
ethanol
methanol
diabetes mellitus
analgesics
anti-inflammatory activity
reflexes
chemical compounds
steroids
hexane

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title = "Phytochemical composition and pharmacological evaluation of different extracts of Oenothera rosea L´H{\'e}r. ex Ait (Onagraceae) aerial part",
abstract = "{\circledC} 2018 South African Association of Botanists Oenothera genus consists of 145 herbs species which has been used for the treatment of skin diseases, diabetes mellitus, renal and liver problems, and as anti-diarrheic and anti-inflammatory drugs, among others. A great variety of chemical compounds have been reported from Oenothera genus among them tannins, flavonoids, steroids, carbohydrates and lipids. This study was focused on investigating the effect of different extracts of Oenothera rosea L´ H{\'e}r. ex Ait aerial part (from water ethanol, methanol, ethyl acetate, chloroform and hexane) on total flavonoid and phenolic compounds content; as well as the evaluation of their antioxidant, analgesic and anti-inflammatory activities. Antioxidant activity was performed considering the ability of the extracts to scavenge DPPH• free radicals, while analgesic and anti-inflammatory activities of most potent extracts were evaluated by acetic acid writhing reflex, hot plate and cotton pellet-induced granuloma formation models, respectively. Methanol, ethanol and ethyl acetate extracts showed a high phenolic compounds content, being ethanol the best solvent for extraction of flavonoids (28.84 ± 0.46 mg flavonoids/g extract). The highest antioxidant activity was observed with methanol, hexane and ethyl acetate extracts (89.51 ± 0.38, 89.42 ± 0.42 and 89.05 ± 0.34{\%}, respectively). Ethanol and ethyl acetate extracts showed analgesic activity with inhibition percentages of the evaluated parameters of more than 50{\%}. Ethyl acetate extract down-regulated chronic inflammation without inducing gastrointestinal damage. These findings provide scientific evidence of O. rosea folkloric use and highlight their importance as a possible natural treatment for several diseases.",
author = "M{\'a}rquez-Flores, {Y. K.} and Mel{\'e}ndez-Camargo, {M. E.} and Garc{\'i}a-Mateos, {N. J.} and Huerta-Anaya, {M. C.} and Pablo-P{\'e}rez, {S. S.} and R. Silva-Torres",
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Phytochemical composition and pharmacological evaluation of different extracts of Oenothera rosea L´Hér. ex Ait (Onagraceae) aerial part. / Márquez-Flores, Y. K.; Meléndez-Camargo, M. E.; García-Mateos, N. J.; Huerta-Anaya, M. C.; Pablo-Pérez, S. S.; Silva-Torres, R.

In: South African Journal of Botany, 01.05.2018, p. 245-250.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Phytochemical composition and pharmacological evaluation of different extracts of Oenothera rosea L´Hér. ex Ait (Onagraceae) aerial part

AU - Márquez-Flores, Y. K.

AU - Meléndez-Camargo, M. E.

AU - García-Mateos, N. J.

AU - Huerta-Anaya, M. C.

AU - Pablo-Pérez, S. S.

AU - Silva-Torres, R.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - © 2018 South African Association of Botanists Oenothera genus consists of 145 herbs species which has been used for the treatment of skin diseases, diabetes mellitus, renal and liver problems, and as anti-diarrheic and anti-inflammatory drugs, among others. A great variety of chemical compounds have been reported from Oenothera genus among them tannins, flavonoids, steroids, carbohydrates and lipids. This study was focused on investigating the effect of different extracts of Oenothera rosea L´ Hér. ex Ait aerial part (from water ethanol, methanol, ethyl acetate, chloroform and hexane) on total flavonoid and phenolic compounds content; as well as the evaluation of their antioxidant, analgesic and anti-inflammatory activities. Antioxidant activity was performed considering the ability of the extracts to scavenge DPPH• free radicals, while analgesic and anti-inflammatory activities of most potent extracts were evaluated by acetic acid writhing reflex, hot plate and cotton pellet-induced granuloma formation models, respectively. Methanol, ethanol and ethyl acetate extracts showed a high phenolic compounds content, being ethanol the best solvent for extraction of flavonoids (28.84 ± 0.46 mg flavonoids/g extract). The highest antioxidant activity was observed with methanol, hexane and ethyl acetate extracts (89.51 ± 0.38, 89.42 ± 0.42 and 89.05 ± 0.34%, respectively). Ethanol and ethyl acetate extracts showed analgesic activity with inhibition percentages of the evaluated parameters of more than 50%. Ethyl acetate extract down-regulated chronic inflammation without inducing gastrointestinal damage. These findings provide scientific evidence of O. rosea folkloric use and highlight their importance as a possible natural treatment for several diseases.

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