TY - JOUR
T1 - Photoacoustic Spectroscopy and Hyperglycemia in Experimental Type 1 Diabetes
AU - Olvera Cano, Lilia I.
AU - Villanueva Lopez, Guadalupe C.
AU - Mateos, Evelyn Romero
AU - Orea, Alfredo Cruz
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2021/12
Y1 - 2021/12
N2 - According to the World Health Organization, diabetes was the seventh leading cause of death in 2016. Long-term diabetes complications are associated with hyperglycemia. It is difficult to predict the beginning and evolution of those complications. The goal of the study was to evaluate the relationship between glycemia and blood spectroscopic variables in an experimental model of type 1 diabetes (streptozotocin model). Blood samples were taken weekly (10 weeks) from the tail of male Wistar rats with or without diabetes. Blood optical absorption spectra were obtained by means of photoacoustic spectroscopy. It was possible to estimate the time-course of blood characteristic peak ratios. The area under the curve of those peaks correlated with hyperglycemia. The evolution of the optical absorption at 450 nm, related to cytochrome p450, was obtained by using the phase-resolved method. The area under the curve of p450 correlated also with hyperglycemia. It is concluded that photoacoustic spectroscopy is a reliable technology to detect the effects of hyperglycemia on blood with possible applications in the study of long-term diabetes complications.
AB - According to the World Health Organization, diabetes was the seventh leading cause of death in 2016. Long-term diabetes complications are associated with hyperglycemia. It is difficult to predict the beginning and evolution of those complications. The goal of the study was to evaluate the relationship between glycemia and blood spectroscopic variables in an experimental model of type 1 diabetes (streptozotocin model). Blood samples were taken weekly (10 weeks) from the tail of male Wistar rats with or without diabetes. Blood optical absorption spectra were obtained by means of photoacoustic spectroscopy. It was possible to estimate the time-course of blood characteristic peak ratios. The area under the curve of those peaks correlated with hyperglycemia. The evolution of the optical absorption at 450 nm, related to cytochrome p450, was obtained by using the phase-resolved method. The area under the curve of p450 correlated also with hyperglycemia. It is concluded that photoacoustic spectroscopy is a reliable technology to detect the effects of hyperglycemia on blood with possible applications in the study of long-term diabetes complications.
KW - Type 1 diabetes
KW - blood optical absorption
KW - hyperglycemia
KW - photoacoustic spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85116358406&partnerID=8YFLogxK
U2 - 10.1177/00037028211047257
DO - 10.1177/00037028211047257
M3 - Artículo
C2 - 34596452
AN - SCOPUS:85116358406
SN - 0003-7028
VL - 75
SP - 1465
EP - 1474
JO - Applied Spectroscopy
JF - Applied Spectroscopy
IS - 12
ER -