TY - JOUR
T1 - Pharmacokinetics of Oral Nifedipine in Different Populations
AU - Castañeda‐Hernández, G.
AU - Hoyo‐Vadillo, C.
AU - Palma‐Aguirre, J. A.
AU - Flores‐Murrieta, F. J.
PY - 1993/2
Y1 - 1993/2
N2 - Nifedipine disposition varies among populations. Reports on oral nifedipine pharmacokinetics show that peak plasma levels and AVC values are higher in Mexican and Japanese than in European and North American subjects. Increased nifedipine bioavailability in the nonwhite populations is likely due to nutritional habits. Certain flavonoids that inhibit the first‐pass metabolism of dihydropyridines are present in the diets of both Mexican and Japanese. Differences in phenotypes may play a role in interethnic variability. 1993 American College of Clinical Pharmacology
AB - Nifedipine disposition varies among populations. Reports on oral nifedipine pharmacokinetics show that peak plasma levels and AVC values are higher in Mexican and Japanese than in European and North American subjects. Increased nifedipine bioavailability in the nonwhite populations is likely due to nutritional habits. Certain flavonoids that inhibit the first‐pass metabolism of dihydropyridines are present in the diets of both Mexican and Japanese. Differences in phenotypes may play a role in interethnic variability. 1993 American College of Clinical Pharmacology
UR - http://www.scopus.com/inward/record.url?scp=0027535372&partnerID=8YFLogxK
U2 - 10.1002/j.1552-4604.1993.tb03934.x
DO - 10.1002/j.1552-4604.1993.tb03934.x
M3 - Artículo
SN - 0091-2700
VL - 33
SP - 140
EP - 145
JO - Journal of Clinical Pharmacology
JF - Journal of Clinical Pharmacology
IS - 2
ER -