TY - JOUR
T1 - Patents on phytochemicals
T2 - Methodologies of extraction, application in food and pharmaceutical industry
AU - Ordaz-Trinidad, Nancy
AU - Dorantes-Alvarez, Lidia
AU - Salas-Benito, Juan
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Background: Patents on phytochemicals are being registered worldwide. Such phytochemicals provide benefits to human health, and include terpenoids, phenolic compounds, alkaloids, lignin, and fiber. Objective: This review has the purpose to provide a comprehensive overview of patents published in the last five years about extraction of phytochemicals and their application in the food and pharmaceutical industry. Method: Forty eight patents were analyzed and classified in four topics of interest; 1) Extraction, 2) Functional foods, 3) Biological activity, and 4) Prevention of diseases. Results: Extraction yield of phytochemicals is the critical step. The techniques to extract phytochemicals include enzymatic hydrolysis, nano-particulate precipitation, salts formation and combination of solvents; however, the use of ultrasound and microwave is increasing. Patents concerning functional foods include pediatric formulations, sport drink, and compositions that produce beneficial effects. Biological activity of plant extracts tested in animals or cell cultures, as antioxidant, anti-inflammatory, anticancer activity, reduction of obesity and diabetes are presented in this review. Application of phy-tochemicals in the prevention and treatment of health disorders, such as diabetes, gastritis, enteritis, topical inflammation, macular degeneration, gingivitis, prostatic hyperplasia, urinary impairments. Conclusion: Patents revised include 30% methodologies for extraction of phytochemicals, 16% application of phytochem-icals in food matrixes to obtain functional foods, 18% biological activity of extracts or compounds and 36% application in the prevention and treatment of illness, which reveals a great interest to protect intellectual property concerning application of phytochemicals formulations for human health.
AB - Background: Patents on phytochemicals are being registered worldwide. Such phytochemicals provide benefits to human health, and include terpenoids, phenolic compounds, alkaloids, lignin, and fiber. Objective: This review has the purpose to provide a comprehensive overview of patents published in the last five years about extraction of phytochemicals and their application in the food and pharmaceutical industry. Method: Forty eight patents were analyzed and classified in four topics of interest; 1) Extraction, 2) Functional foods, 3) Biological activity, and 4) Prevention of diseases. Results: Extraction yield of phytochemicals is the critical step. The techniques to extract phytochemicals include enzymatic hydrolysis, nano-particulate precipitation, salts formation and combination of solvents; however, the use of ultrasound and microwave is increasing. Patents concerning functional foods include pediatric formulations, sport drink, and compositions that produce beneficial effects. Biological activity of plant extracts tested in animals or cell cultures, as antioxidant, anti-inflammatory, anticancer activity, reduction of obesity and diabetes are presented in this review. Application of phy-tochemicals in the prevention and treatment of health disorders, such as diabetes, gastritis, enteritis, topical inflammation, macular degeneration, gingivitis, prostatic hyperplasia, urinary impairments. Conclusion: Patents revised include 30% methodologies for extraction of phytochemicals, 16% application of phytochem-icals in food matrixes to obtain functional foods, 18% biological activity of extracts or compounds and 36% application in the prevention and treatment of illness, which reveals a great interest to protect intellectual property concerning application of phytochemicals formulations for human health.
KW - Anticancer phytochemicals
KW - Antihyperglicemic activity
KW - Functional foods
KW - Physiological benefits
KW - Phytochemicals extraction
KW - Prevention diseases
UR - http://www.scopus.com/inward/record.url?scp=84975701605&partnerID=8YFLogxK
U2 - 10.2174/1872208310999160317145333
DO - 10.2174/1872208310999160317145333
M3 - Artículo
SN - 1872-2083
VL - 9
SP - 158
EP - 167
JO - Recent Patents on Biotechnology
JF - Recent Patents on Biotechnology
IS - 3
ER -