Organocatalytic cycloaddition reaction: A gateway for molecular complexity

The organocatalysis is the process of using small organic molecules to accelerate the reaction course without affecting the equilibrium position. The small organic compounds that have these catalytic effects are commonly referred to as organocatalysts. In recent years, the use of small organic molecules as catalysts has gained tremendous attention in the synthesis of complex organic molecules. The organocatalyzed reactions have several advantages over other existing transition metal or organometallic-mediated methodology for the asymmetric synthesis. This includes the use of less toxic, environmental benign and highly economical procedures. This present study intends to compile the exciting methods based on organocatalytic cycloaddition strategies for the synthesis of unique complex bioactive molecules and their application in the diverse fields.