Noveon AA1 as a matrix for controlled release of direct compression tablets

This work evaluates the Noveon AA1 functionality as an excipient for controlled release tablets. The effect of variables was determined using dissolution profiles, compactibility profiles and the powders flowability. Noveon AA1 hydrates in unstirred water and after 90 minutes begins to lose its integrity. The compactibility of Noveon AA1 (Dmax = 484 N) is higher than that of other excipients. Noveon AA1 exhibits a poor powder flow 0.0372 g/s and a compressibility index of 39%. Noveon AA1 provokes a decrease in drug dissolution of 2.9% and an increase in compactibility of 3.0 N, for every unit percentage of added excipient. Noveon AA1 increases the compressibility index of Metronidazole. Addition of 4% Aerosil reduces the formulation compressibility index to 21.5%, considered to be at the limit of processability. Noveon AA1 displays good controlled release properties, a better compactibility than other agglutinants and a poor flowability that can be improved with Aerosil.