Novel synthesis of isoindoline/isoindoline-1,3-dione derivatives under solventless conditions and evaluation with the human D₂ receptor

Medicine & Life Sciences

• isoindoline-1,3-dione 100%
• Dopamine D2 Receptors 55%
• Parkinsonian Disorders 51%
• Computer Simulation 44%
• human DRD2 protein 42%
• Pharmacokinetics 35%
• Allosteric Site 33%
• Quantitative Structure-Activity Relationship 32%
• Biogenic Amines 30%
• Molecular Models 30%
• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 29%
• Heating 25%
• Binding Sites 18%
• Ligands 16%
• Amino Acids 16%

Chemistry

• Dopamine 44%
• 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 25%
• Pharmacokinetics 23%
• Green Chemistry 17%
• Molecule 16%
• Amino-Acid Residue 13%
• Binding Energy 13%
• Binding Site 10%
• Green 10%
• Crystal Structure 7%
• Ligand 6%