Abstract
The Photoacoustic Spectroscopy, based on the generation of acoustic waves following the absorption of the modulated light by an enclosed material, was discovered in 1880 by Alexander Graham Bell. There are a lot of remarkable achievements in this topic since those days. It has been intended to present a relatively new tool to the researchers in biological areas and, simultaneously, to propose new fields of investigation to those who have been attracted by physics. The application of Photoacoustic trace gas detection to the determination of ethylene content in mice exhalation is described as a biomarker of free radicals production. It has been demonstrated the feasibility of studying the lipid peroxidation in vivo by this technique. Specifically, the results of δ-aminolevulinic acid administration in mice are presented. This drug has been used to induce Protoporphyrin IX production and ultimately to apply the Photodynamic Therapy, a recent method in cancer treatment. A kinetic study of Protoporphyrin IX production in mice skin and blood after δ-aminolevulinic acid administration in different doses is also shown. This study was performed using Photoacoustic Spectroscopy in solids.
| Original language | English |
|---|---|
| Article number | 27 |
| Pages (from-to) | 148-153 |
| Number of pages | 6 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 5622 |
| Issue number | PART 1 |
| DOIs | |
| State | Published - 2004 |
| Externally published | Yes |
| Event | RIAO/OPTILAS 2004: 5th Iberoamerican Meeting on Optics, and 8th Latin American Meeting on Optics, Lasers, and their Applications; ICO Regional Meeting - Porlamar, Venezuela, Bolivarian Republic of Duration: 3 Oct 2004 → 8 Oct 2004 |
Keywords
- Photoacoustic spectroscopy
- Photodynamic therapy
