TY - JOUR
T1 - New therapeutic targets for drug design against Trypanosoma cruzi, advances and perspectives
AU - Rivera, Gildardo
AU - Bocanegra-García, Virgilio
AU - Ordaz-Pichardo, Cynthia
AU - Nogueda-Torres, Benjamin
AU - Monge, Antonio
PY - 2009
Y1 - 2009
N2 - Chagas disease is one of the most important parasitic diseases in Latin America, affecting16 to 18 million people. Nifurtimox and Benznidazol are drugs that are commonly used in its treatment; however, these drugs produce several adverse reactions and are not effective in the chronic phase of the disease. Therefore, the design, synthesis, and biological evaluation of new compounds with potential activity against Trypanozoma cruzi are of great importance. We review six proteins involved in the biochemical metabolism of Trypanosoma cruzi that have recently been studied as potential targets for designing new drugs for Chagas disease. These are farnesyl pyrophosphate synthase, trans-sialidase, cruzain cystein protease, trypanothione reductase, glucose 6-phosphate- dehydrogenase, glyceraldehyde 3-phosphatedehydrogenase, and α-hydroxy acid dehydrogenase. We also review the advances of compounds recently designed based on structure-activity, and the perspectives of new compounds that inhibit these therapeutic targets.
AB - Chagas disease is one of the most important parasitic diseases in Latin America, affecting16 to 18 million people. Nifurtimox and Benznidazol are drugs that are commonly used in its treatment; however, these drugs produce several adverse reactions and are not effective in the chronic phase of the disease. Therefore, the design, synthesis, and biological evaluation of new compounds with potential activity against Trypanozoma cruzi are of great importance. We review six proteins involved in the biochemical metabolism of Trypanosoma cruzi that have recently been studied as potential targets for designing new drugs for Chagas disease. These are farnesyl pyrophosphate synthase, trans-sialidase, cruzain cystein protease, trypanothione reductase, glucose 6-phosphate- dehydrogenase, glyceraldehyde 3-phosphatedehydrogenase, and α-hydroxy acid dehydrogenase. We also review the advances of compounds recently designed based on structure-activity, and the perspectives of new compounds that inhibit these therapeutic targets.
KW - Chagas disease
KW - Drug design
KW - Therapeutic targets
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=70450210789&partnerID=8YFLogxK
U2 - 10.2174/092986709788803303
DO - 10.2174/092986709788803303
M3 - Artículo de revisión
SN - 0929-8673
VL - 16
SP - 3286
EP - 3293
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 25
ER -