TY - JOUR
T1 - New insights into the pathophysiology of nonalcoholic fatty liver disease
AU - Chavez-Tapia, Norberto C.
AU - Uribe, Misael
AU - Ponciano-Rodriguez, Guadalupe
AU - Medina-Santillan, Roberto
AU - Mendez-Sanchez, Nahum
PY - 2009
Y1 - 2009
N2 - The consequences of pathologic adipose tissue accumulation have been described for almost all organs. Nonalcoholic fatty liver disease (NAFLD) is considered the most relevant hepatic manifestation of obesity. There is great interest in the study of NAFLD, and new insights into its pathogenic process have been described. Currently, in addition to insulin resistance, which was considered the hallmark of this disease, endocrine, immu-nologic, and central nervous system factors are attracting interest as explanatory variables. In this review, new factors associated with the main theories on the pathophysiology of NAFLD are analyzed.
AB - The consequences of pathologic adipose tissue accumulation have been described for almost all organs. Nonalcoholic fatty liver disease (NAFLD) is considered the most relevant hepatic manifestation of obesity. There is great interest in the study of NAFLD, and new insights into its pathogenic process have been described. Currently, in addition to insulin resistance, which was considered the hallmark of this disease, endocrine, immu-nologic, and central nervous system factors are attracting interest as explanatory variables. In this review, new factors associated with the main theories on the pathophysiology of NAFLD are analyzed.
KW - Fatty acids
KW - Immune response
KW - Insulin resistance
KW - Steatosis
KW - Vagus nerve
UR - http://www.scopus.com/inward/record.url?scp=66749190009&partnerID=8YFLogxK
U2 - 10.1016/s1665-2681(19)31821-6
DO - 10.1016/s1665-2681(19)31821-6
M3 - Artículo
SN - 1665-2681
VL - 8
SP - S9-S17
JO - Annals of Hepatology
JF - Annals of Hepatology
IS - SUPPL. 1
ER -