TY - JOUR
T1 - Neuroprotective actions of the synthetic estrogen 17α- Ethynylestradiol in the hippocampus
AU - Picazo, Ofir
AU - Becerril-Montes, Adriana
AU - Huidobro-Perez, Delia
AU - Garcia-Segura, Luis M.
N1 - Funding Information:
Acknowledgements We acknowledge the support for this study from Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional (SIP-IPN), Mexico; Comisión de Operación y Fomento de las Actividades Académicas (COFAA), Mexico, and Ministerio de Ciencia e Innovación, Spain (BFU2008-02950-C03-01).
PY - 2010/7
Y1 - 2010/7
N2 - 17α-Ethynylestradiol (EE2), a major constituent of many oral contraceptives, is similar in structure to 17β-estradiol, which has neuroprotective properties in several animal models. This study explored the potential neuroprotective actions of EE2 against kainic and quinolinic acid toxicity in the hippocampus of adult ovariectomized Wistar rats. A decrease in the number of Nissl-stained neurons and the induction of vimentin immunoreactivity in astrocytes was observed in the hilus of the dentate gyrus of the hippocampus after the administration of either kainic acid or quinolinic acid. EE2 prevented the neuronal loss and the induction of vimentin immunoreactivity induced by kainic acid at low (1 μg/rat) and high (10-100 μg/rat) doses and exerted a protection against quinolinic acid toxicity at a low dose (1 μg/rat) only. These observations demonstrate that EE2 exerts neuroprotective actions against excitotoxic insults. This finding is relevant for the design of new neuroprotective estrogenic compounds.
AB - 17α-Ethynylestradiol (EE2), a major constituent of many oral contraceptives, is similar in structure to 17β-estradiol, which has neuroprotective properties in several animal models. This study explored the potential neuroprotective actions of EE2 against kainic and quinolinic acid toxicity in the hippocampus of adult ovariectomized Wistar rats. A decrease in the number of Nissl-stained neurons and the induction of vimentin immunoreactivity in astrocytes was observed in the hilus of the dentate gyrus of the hippocampus after the administration of either kainic acid or quinolinic acid. EE2 prevented the neuronal loss and the induction of vimentin immunoreactivity induced by kainic acid at low (1 μg/rat) and high (10-100 μg/rat) doses and exerted a protection against quinolinic acid toxicity at a low dose (1 μg/rat) only. These observations demonstrate that EE2 exerts neuroprotective actions against excitotoxic insults. This finding is relevant for the design of new neuroprotective estrogenic compounds.
KW - Estrogens
KW - Excitotoxicity
KW - Kainic acid
KW - Neurodegeneration
KW - Quinolinic acid
KW - Reactive astroglia
UR - http://www.scopus.com/inward/record.url?scp=77956265551&partnerID=8YFLogxK
U2 - 10.1007/s10571-009-9490-3
DO - 10.1007/s10571-009-9490-3
M3 - Artículo
C2 - 20044777
SN - 0272-4340
VL - 30
SP - 675
EP - 682
JO - Cellular and Molecular Neurobiology
JF - Cellular and Molecular Neurobiology
IS - 5
ER -