TY - JOUR
T1 - Neuropharmacological Profile of Hydroalcohol Extract of Valeriana edulis ssp. procera Roots in Mice
AU - Oliva, Iván
AU - González-Trujano, Ma Eva
AU - Arrieta, Jesús
AU - Enciso-Rodríguez, Roberto
AU - Navarrete, Andrés
PY - 2004/4
Y1 - 2004/4
N2 - Valerian is the common name given to the crude drug consisting of the underground organs of the species Valeriana. Valeriana edulis ssp. procera Meyer is the Mexican valerian. The aim of the present work was to elucidate the neuropharmacological profile of a hydroalcohol extract of Valeriana edulis roots at doses of 100, 300 and 1000 mg/kg in several experimental models. A dose-dependent anticonvulsant and anxiolytic-like effect of V. edulis was demonstrated. In addition, the extract decreased rotarod performance and traction force and prolonged the pentobarbital-induced sleeping time at high doses. Concomitant administration of valerian extract and pentobarbital showed a synergistic effect on motor coordination and traction force in mice. The anxiolytic-like effect of V. edulis was compared with diazepam and with diphenhydramine and doxylamine, the latter in order to consider the H 1-antihistamine effect as another possibility to explain, at least in part, the central nervous system depressant effect of valerian. These results also underlie the medical and industrial use of this species and allowed the conclusion that the extract of V. edulis has central nervous depressant properties similar to, but with some differences to V. officinalis, a very well known species.
AB - Valerian is the common name given to the crude drug consisting of the underground organs of the species Valeriana. Valeriana edulis ssp. procera Meyer is the Mexican valerian. The aim of the present work was to elucidate the neuropharmacological profile of a hydroalcohol extract of Valeriana edulis roots at doses of 100, 300 and 1000 mg/kg in several experimental models. A dose-dependent anticonvulsant and anxiolytic-like effect of V. edulis was demonstrated. In addition, the extract decreased rotarod performance and traction force and prolonged the pentobarbital-induced sleeping time at high doses. Concomitant administration of valerian extract and pentobarbital showed a synergistic effect on motor coordination and traction force in mice. The anxiolytic-like effect of V. edulis was compared with diazepam and with diphenhydramine and doxylamine, the latter in order to consider the H 1-antihistamine effect as another possibility to explain, at least in part, the central nervous system depressant effect of valerian. These results also underlie the medical and industrial use of this species and allowed the conclusion that the extract of V. edulis has central nervous depressant properties similar to, but with some differences to V. officinalis, a very well known species.
KW - Anticonvulsant
KW - Anxiolytic
KW - Depressant
KW - Sedative
KW - Valerian
KW - Valeriana edulis ssp. procera
UR - http://www.scopus.com/inward/record.url?scp=2442622380&partnerID=8YFLogxK
U2 - 10.1002/ptr.1389
DO - 10.1002/ptr.1389
M3 - Artículo
SN - 0951-418X
VL - 18
SP - 290
EP - 296
JO - Phytotherapy Research
JF - Phytotherapy Research
IS - 4
ER -