TY - JOUR
T1 - Neurological Involvement in Pediatric Patients with Acute Leukemia
T2 - A Retrospective Cohort
AU - Cruz-Chávez, Diana Alejandra
AU - López-Pérez, Brian Javier
AU - Solórzano-Gómez, Elsa
AU - Venta-Sobero, José Antonio
AU - Flores-Villegas, Luz Victoria
AU - Toledo-Lozano, Christian Gabriel
AU - Castro-Loza, Gabriela Vianney
AU - Sandoval-Pacheco, Roberto
AU - Torres-Vallejo, Andrea
AU - Marmol-Realpe, Karen Sharlot Faisury
AU - Flores-Jurado, Yazmín Evelyn
AU - Hernández-Soriano, Cristal Lucero
AU - Alcaraz-Estrada, Sofía Lizeth
AU - Mondragón-Terán, Paul
AU - Suárez-Cuenca, Juan Antonio
AU - Coral-Vázquez, Ramón Mauricio
AU - Garcia, Silvia
N1 - Publisher Copyright:
© 2022 by the authors.
PY - 2022/9
Y1 - 2022/9
N2 - Acute leukemia (AL) is an important cause of morbidity and mortality in children, and neurological manifestations (NM) are frequent. The objective of this study was to analyze neurological manifestations in children with acute leukemia from cases attended in the last five years at the Centro Médico Nacional “20 de Noviembre”. Methods: Conducting a retrospective and analytical study from 1 January 2015 to 31 December 2020 in children with AL classified according to sex, age range and AL type. Participants were grouped according the presence of NM. Results: We analyzed 607 patients: 54.85% boys and 44.14% girls, with a mean age of 7.27 ± 4.54 years. When comparing groups, the NM group was significantly older (p = 0.01), and the highest prevalence was between 6 and 12 years old. ALL was predominant over the other lineages (p ≤ 0.01). The most frequent NM was CNS infiltration, seizures, headache and neuropathy. Death outcomes occurred in 18.7% of children with AML, 11.8% with ALL and 50% with MPAL (p ≤ 0.002). The NM group was associated with higher mortality during a follow-up time of 77.9 ± 49 months (44.4% vs. 8.9% deaths, NM vs. non-NM, respectively; OR = 3.3; 95% CI 2.4 to 4.6; p ≤ 0.0001). Conclusions: ALL was the most prevalent leukemia type. CNS infiltration, seizures, headache, neuropathy and PRES were the most frequent symptoms in the NM group. NM was associated with a higher mortality rate.
AB - Acute leukemia (AL) is an important cause of morbidity and mortality in children, and neurological manifestations (NM) are frequent. The objective of this study was to analyze neurological manifestations in children with acute leukemia from cases attended in the last five years at the Centro Médico Nacional “20 de Noviembre”. Methods: Conducting a retrospective and analytical study from 1 January 2015 to 31 December 2020 in children with AL classified according to sex, age range and AL type. Participants were grouped according the presence of NM. Results: We analyzed 607 patients: 54.85% boys and 44.14% girls, with a mean age of 7.27 ± 4.54 years. When comparing groups, the NM group was significantly older (p = 0.01), and the highest prevalence was between 6 and 12 years old. ALL was predominant over the other lineages (p ≤ 0.01). The most frequent NM was CNS infiltration, seizures, headache and neuropathy. Death outcomes occurred in 18.7% of children with AML, 11.8% with ALL and 50% with MPAL (p ≤ 0.002). The NM group was associated with higher mortality during a follow-up time of 77.9 ± 49 months (44.4% vs. 8.9% deaths, NM vs. non-NM, respectively; OR = 3.3; 95% CI 2.4 to 4.6; p ≤ 0.0001). Conclusions: ALL was the most prevalent leukemia type. CNS infiltration, seizures, headache, neuropathy and PRES were the most frequent symptoms in the NM group. NM was associated with a higher mortality rate.
KW - acute leukemia
KW - children
KW - neurological manifestations
UR - http://www.scopus.com/inward/record.url?scp=85138543190&partnerID=8YFLogxK
U2 - 10.3390/children9091268
DO - 10.3390/children9091268
M3 - Artículo
C2 - 36138577
AN - SCOPUS:85138543190
SN - 2227-9067
VL - 9
JO - Children
JF - Children
IS - 9
M1 - 1268
ER -