TY - JOUR
T1 - Nephroprotective activity of prosthechea michuacana against cisplatin-induced acute renal failure in rats
AU - Gutierrez, Rosa Martha Perez
AU - Gomez, Yolanda Gomez Y.
AU - Ramirez, Esther Bautista
PY - 2010/8/1
Y1 - 2010/8/1
N2 - In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury model in rats. Results showed that treatment with cisplatin induced significant elevations in concentrations of blood urea and serum creatinine and in lipid peroxidation. Treatments with methanolic extract (200, 400 and 500 mg/kg) increased levels of biochemical markers of renal injury like reduced glutathione, glutathione S-transferase, and superoxide dismutase and inhibited the increases in blood urea and serum creatinine concentrations and lipid peroxidation induced by cisplatin. Hexane and chloroform extracts did not show any effect. The results obtained in the present study indicate that this orchid can be a potential source of natural nephroprotective activity.
AB - In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury model in rats. Results showed that treatment with cisplatin induced significant elevations in concentrations of blood urea and serum creatinine and in lipid peroxidation. Treatments with methanolic extract (200, 400 and 500 mg/kg) increased levels of biochemical markers of renal injury like reduced glutathione, glutathione S-transferase, and superoxide dismutase and inhibited the increases in blood urea and serum creatinine concentrations and lipid peroxidation induced by cisplatin. Hexane and chloroform extracts did not show any effect. The results obtained in the present study indicate that this orchid can be a potential source of natural nephroprotective activity.
KW - Prosthechea michuacana
KW - biochemical parameters
KW - cisplatin
UR - http://www.scopus.com/inward/record.url?scp=77955221287&partnerID=8YFLogxK
U2 - 10.1089/jmf.2009.0175
DO - 10.1089/jmf.2009.0175
M3 - Artículo
SN - 1096-620X
VL - 13
SP - 911
EP - 916
JO - Journal of Medicinal Food
JF - Journal of Medicinal Food
IS - 4
ER -