TY - JOUR
T1 - Nanodrugs against cancer
T2 - biological considerations in its redesign
AU - Flores de los Rios, P. A.
AU - Casañas Pimentel, R. G.
AU - San Martín Martínez, E.
N1 - Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - Cancer is a public health problem throughout the world as incidence and mortality rates are increasing year after year. Although conventional therapies such as chemotherapy and radiation show favorable results against this disease, the side effects it causes throughout the body reduce the quality of life of the patient. Therefore, nanomedicine offers us new promising tools to attack cancer through the innovation of nanodrugs, to increase the therapeutic response, reduce dosage, and without generating as many side effects as conventional therapies. For the design of nanodrugs, it is essential to know the biological barriers of the organism and the cancer barriers faced by nanodrugs, such as cell membrane openings, the solubility of the drugs to be transported, and surface electric charge and the protein corona. Due to the aforementioned, the purpose of this review article is to delve into the long journey that nanodrugs undertake from the moment they are administered until they are internalized in tumor cells, taking into account some of the biological and molecular challenges that they defy to reach to its final destination, to observe a desired therapeutic response in the cancer patient.
AB - Cancer is a public health problem throughout the world as incidence and mortality rates are increasing year after year. Although conventional therapies such as chemotherapy and radiation show favorable results against this disease, the side effects it causes throughout the body reduce the quality of life of the patient. Therefore, nanomedicine offers us new promising tools to attack cancer through the innovation of nanodrugs, to increase the therapeutic response, reduce dosage, and without generating as many side effects as conventional therapies. For the design of nanodrugs, it is essential to know the biological barriers of the organism and the cancer barriers faced by nanodrugs, such as cell membrane openings, the solubility of the drugs to be transported, and surface electric charge and the protein corona. Due to the aforementioned, the purpose of this review article is to delve into the long journey that nanodrugs undertake from the moment they are administered until they are internalized in tumor cells, taking into account some of the biological and molecular challenges that they defy to reach to its final destination, to observe a desired therapeutic response in the cancer patient.
KW - Cancer
KW - cell
KW - chemotherapy
KW - nanodrugs
KW - nanomedicine
UR - http://www.scopus.com/inward/record.url?scp=85134372394&partnerID=8YFLogxK
U2 - 10.1080/00914037.2022.2097680
DO - 10.1080/00914037.2022.2097680
M3 - Artículo de revisión
AN - SCOPUS:85134372394
SN - 0091-4037
VL - 72
SP - 1340
EP - 1359
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 17
ER -