TY - JOUR
T1 - N-substituted ephedrines as chiral auxiliaries in enantioselective alkylation reactions of carbonyl compounds
AU - Cruz, Alejandro
AU - Padilla-Martínez, Itzia Irene
AU - Bautista-Ramírez, María Esther
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016
Y1 - 2016
N2 - The synthesis of high optical purity chiral compounds is of current importance in organic and organometallic areas of the chemistry with further boost. Chiral compounds are important because of wide use in many areas such as pharmacy and food industry, etc. Reagents, catalysts or chiral auxiliaries that can control the stereochemistry of the products are required for the synthesis of chiral compounds. Furthermore, the reagents used must be able to be recycled. In recent decades, Ephedra derivative compounds have been widely used as catalyst chiral ligands or chiral inductors in asymmetric synthesis. To our knowledge, no review about Ephedra derivative compounds as chiral auxiliaries used with organometallics in alkylation reactions to carbonyl compounds, has been published. In this paper, the use of N-substituted and N-disubstituted ephedra compounds as chiral auxiliary ligands in alkylation, alkenylation and alquinilation reactions of carbonyl and imine compounds is summarized.
AB - The synthesis of high optical purity chiral compounds is of current importance in organic and organometallic areas of the chemistry with further boost. Chiral compounds are important because of wide use in many areas such as pharmacy and food industry, etc. Reagents, catalysts or chiral auxiliaries that can control the stereochemistry of the products are required for the synthesis of chiral compounds. Furthermore, the reagents used must be able to be recycled. In recent decades, Ephedra derivative compounds have been widely used as catalyst chiral ligands or chiral inductors in asymmetric synthesis. To our knowledge, no review about Ephedra derivative compounds as chiral auxiliaries used with organometallics in alkylation reactions to carbonyl compounds, has been published. In this paper, the use of N-substituted and N-disubstituted ephedra compounds as chiral auxiliary ligands in alkylation, alkenylation and alquinilation reactions of carbonyl and imine compounds is summarized.
KW - Asymmetric synthesis
KW - Chiral auxiliaries
KW - Enantioselectivity
KW - Ephedrines
KW - Organometallics
UR - http://www.scopus.com/inward/record.url?scp=84958963431&partnerID=8YFLogxK
U2 - 10.2174/1570179412666150514000239
DO - 10.2174/1570179412666150514000239
M3 - Artículo
AN - SCOPUS:84958963431
SN - 1570-1794
VL - 13
SP - 2
EP - 40
JO - Current Organic Synthesis
JF - Current Organic Synthesis
IS - 1
ER -