TY - JOUR
T1 - Muscle function and age are associated with loss of bone mineral density in Duchenne muscular dystrophy
AU - Del Rocío Cruz-Guzmán, Oriana
AU - Rodríguez-Cruz, Maricela
AU - Almeida-Becerril, Tomas
AU - Maldonado-Hernández, Jorge
AU - Baeza, Carlos Wong
N1 - Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/4
Y1 - 2019/4
N2 - Introduction: Patients with Duchenne muscular dystrophy (DMD) demonstrate decreased bone mineral density (BD). It is not clear which factors exert the greatest impact on BD loss in these patients. Methods: In 63 patients with DMD, serum cytokines (interleukin [IL]-1, IL-6, and tumor necrosis factor-beta [TNF-β]), C-reactive protein (CRP), creatine kinase (CK), muscle function (by Vignos scale), body composition, and total BD (the latter 2 measured by dual-energy X-ray absorptiometry, or DEXA) were determined. Results: The main factors associated with BD loss were muscle function (34.0%; β = −0.139; P < 0.023) and age (36.7%; β = −0.151; P = 0.004). Cytokines, CRP, body fat mass, and CK did not contribute to BD loss. Discussion: Muscle function and age contribute to BD loss in DMD. We propose that a cut-off of at least 6 points for the Vignos scale and at least 10.5 years of age predict a Z-score of less than or equal to −2.0. Muscle Nerve 59:417–421, 2019.
AB - Introduction: Patients with Duchenne muscular dystrophy (DMD) demonstrate decreased bone mineral density (BD). It is not clear which factors exert the greatest impact on BD loss in these patients. Methods: In 63 patients with DMD, serum cytokines (interleukin [IL]-1, IL-6, and tumor necrosis factor-beta [TNF-β]), C-reactive protein (CRP), creatine kinase (CK), muscle function (by Vignos scale), body composition, and total BD (the latter 2 measured by dual-energy X-ray absorptiometry, or DEXA) were determined. Results: The main factors associated with BD loss were muscle function (34.0%; β = −0.139; P < 0.023) and age (36.7%; β = −0.151; P = 0.004). Cytokines, CRP, body fat mass, and CK did not contribute to BD loss. Discussion: Muscle function and age contribute to BD loss in DMD. We propose that a cut-off of at least 6 points for the Vignos scale and at least 10.5 years of age predict a Z-score of less than or equal to −2.0. Muscle Nerve 59:417–421, 2019.
KW - Duchenne muscular dystrophy
KW - adipose tissue
KW - bone mineral density
KW - cytokines
KW - inflammation
KW - muscle
UR - http://www.scopus.com/inward/record.url?scp=85060513516&partnerID=8YFLogxK
U2 - 10.1002/mus.26416
DO - 10.1002/mus.26416
M3 - Artículo
C2 - 30623456
AN - SCOPUS:85060513516
SN - 0148-639X
VL - 59
SP - 417
EP - 421
JO - Muscle and Nerve
JF - Muscle and Nerve
IS - 4
ER -