Multicomponent one-pot synthesis of (dihydro-1H-benzo[d]imidazole) phosphonate

José Luis Castrejon-Flores; Oscar Ernesto Guevara-Moreno; Raúl Ricardo Díaz-Contreras; Atilano Gutiérrez-Carrillo; Marco Franco-Pérez; Galdina Vanessa Suárez-Moreno; Angel Zamudio-Medina

doi:10.1080/10426507.2019.1602834

Multicomponent one-pot synthesis of (dihydro-1H-benzo[d]imidazole) phosphonate

José Luis Castrejon-Flores, Oscar Ernesto Guevara-Moreno, Raúl Ricardo Díaz-Contreras, Atilano Gutiérrez-Carrillo, Marco Franco-Pérez, Galdina Vanessa Suárez-Moreno, Angel Zamudio-Medina

Unidad Profesional Interdisciplinaria de Biotecnología (UPIBI)

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We present a multicomponent reaction strategy to synthesize a (dihydro-1H-benzo[d]imidazole)phosphonate family of compounds, using benzimidazoles, diethyl chlorophosphate and aliphatic amines as starting reactants. Giving its simplicity, our procedure involves reaction times of only few hours and avoid the usage of any catalyst agent. All the newly synthesized compounds were characterized by Nuclear Magnetic Resonance spectroscopy (¹H, ¹³C and ³¹P) and mass spectrometry by the DART method.

Original language	English
Pages (from-to)	1062-1066
Number of pages	5
Journal	Phosphorus, Sulfur and Silicon and the Related Elements
Volume	194
Issue number	11
DOIs	https://doi.org/10.1080/10426507.2019.1602834
State	Published - 2 Nov 2019

Keywords

Multicomponent reactions
benzimidazoles
diethyl chlorophosphate

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10.1080/10426507.2019.1602834

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Castrejon-Flores, J. L., Guevara-Moreno, O. E., Díaz-Contreras, R. R., Gutiérrez-Carrillo, A., Franco-Pérez, M., Suárez-Moreno, G. V., & Zamudio-Medina, A. (2019). Multicomponent one-pot synthesis of (dihydro-1H-benzo[d]imidazole) phosphonate. Phosphorus, Sulfur and Silicon and the Related Elements, 194(11), 1062-1066. https://doi.org/10.1080/10426507.2019.1602834

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abstract = "We present a multicomponent reaction strategy to synthesize a (dihydro-1H-benzo[d]imidazole)phosphonate family of compounds, using benzimidazoles, diethyl chlorophosphate and aliphatic amines as starting reactants. Giving its simplicity, our procedure involves reaction times of only few hours and avoid the usage of any catalyst agent. All the newly synthesized compounds were characterized by Nuclear Magnetic Resonance spectroscopy (1H, 13C and 31P) and mass spectrometry by the DART method.",

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T1 - Multicomponent one-pot synthesis of (dihydro-1H-benzo[d]imidazole) phosphonate

AU - Castrejon-Flores, José Luis

AU - Guevara-Moreno, Oscar Ernesto

AU - Díaz-Contreras, Raúl Ricardo

AU - Gutiérrez-Carrillo, Atilano

AU - Franco-Pérez, Marco

AU - Suárez-Moreno, Galdina Vanessa

AU - Zamudio-Medina, Angel

PY - 2019/11/2

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AB - We present a multicomponent reaction strategy to synthesize a (dihydro-1H-benzo[d]imidazole)phosphonate family of compounds, using benzimidazoles, diethyl chlorophosphate and aliphatic amines as starting reactants. Giving its simplicity, our procedure involves reaction times of only few hours and avoid the usage of any catalyst agent. All the newly synthesized compounds were characterized by Nuclear Magnetic Resonance spectroscopy (1H, 13C and 31P) and mass spectrometry by the DART method.

KW - Multicomponent reactions

KW - benzimidazoles

KW - diethyl chlorophosphate

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JO - Phosphorus, Sulfur and Silicon and the Related Elements

JF - Phosphorus, Sulfur and Silicon and the Related Elements

IS - 11

ER -

Multicomponent one-pot synthesis of (dihydro-1H-benzo[d]imidazole) phosphonate

Abstract

Keywords

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