TY - JOUR
T1 - Mouse bone marrow cytogenetic damage produced by residues of tequila
AU - Madrigal-Bujaidar, E.
AU - A., Rojas C.
AU - A., Ramos C.
AU - E., Rosas P.
AU - Díaz Barriga-Arceo, S.
PY - 1990/6
Y1 - 1990/6
N2 - Five concentrations (50-860 mg/kg) of residues obtained after distillation and lyophilization of commercial tequila were injected into mice for evaluation of chromosome aberrations, sister-chromatid exchanges, and proliferation kinetics in mouse bone marrow cells. Appropriate positive and negative controls were included. Our results showed significant dose-related increases of chromosomal aberrations starting at 50 mg/kg and for sister-chromatid exchanges at 430 mg/kg. Cellular proliferation kinetics showed no alterations. With these data we demonstrated that the residues of tequila are genotoxic in vivo.
AB - Five concentrations (50-860 mg/kg) of residues obtained after distillation and lyophilization of commercial tequila were injected into mice for evaluation of chromosome aberrations, sister-chromatid exchanges, and proliferation kinetics in mouse bone marrow cells. Appropriate positive and negative controls were included. Our results showed significant dose-related increases of chromosomal aberrations starting at 50 mg/kg and for sister-chromatid exchanges at 430 mg/kg. Cellular proliferation kinetics showed no alterations. With these data we demonstrated that the residues of tequila are genotoxic in vivo.
KW - Chromosomal aberrations
KW - Mouse bone marrow
KW - Residues of tequila
KW - Sister-chromatid exchanges
UR - http://www.scopus.com/inward/record.url?scp=0025309045&partnerID=8YFLogxK
U2 - 10.1016/0165-1218(90)90116-J
DO - 10.1016/0165-1218(90)90116-J
M3 - Artículo
SN - 0165-1218
VL - 241
SP - 133
EP - 137
JO - Mutation Research - Genetic Toxicology
JF - Mutation Research - Genetic Toxicology
IS - 2
ER -