TY - JOUR
T1 - Morphological and biochemical effects of a low ethanol dose on rat liver regeneration
T2 - Role of route and timing of administration
AU - Morales-González, José A.
AU - Gutiérrez-Salinas, José
AU - Yánez, Lucia
AU - Villagómez-Rico, Carlos
AU - Badillo-Romero, Jesús
AU - Hernández-Munoz, Rolando
N1 - Funding Information:
This work was partially supported by a grant from the Consejo Nacional de Ciencia y Tecnologia (CONACyT 25431-M) . J.A.M.G. is a fellow from CONACyT and DGEP-UNAM. J.G.S. is a fellow from DGAPA-UNAM and PAEP-UNAM.
PY - 1999
Y1 - 1999
N2 - We have demonstrated that in rats subjected to partial hepatectomy (PH), the regenerating liver had an enhanced metabolism of ethanol, which largely depended on the route and timing of ethanol administration. Therefore, the influence of the administration route and timing for ethanol-induced deleterious effects on the regenerating rat liver was evaluated in animals subjected to 70% PH. Remnant liver showed moderate fatty infiltration, extended distortion of hepatocellular structure, and high mitotic index. Intragastric ethanol administration (1.5 g/kg body weight) considerably reduced the PH-induced changes in liver structures. Ethanol treatment also decreased liver thymidine kinase activity, serum albumin, and glucose levels. Intraperitoneal administration of the same ethanol dose to PH rats promoted lesser alterations on liver regeneration. Independently of its administration route, ethanol abruptly shortened a PH-induced selective increase in serum enzyme activities. These data suggest that the inhibitory effect of a low dose of ethanol on PH-induced liver regeneration is dependent on the timing and route of administration.
AB - We have demonstrated that in rats subjected to partial hepatectomy (PH), the regenerating liver had an enhanced metabolism of ethanol, which largely depended on the route and timing of ethanol administration. Therefore, the influence of the administration route and timing for ethanol-induced deleterious effects on the regenerating rat liver was evaluated in animals subjected to 70% PH. Remnant liver showed moderate fatty infiltration, extended distortion of hepatocellular structure, and high mitotic index. Intragastric ethanol administration (1.5 g/kg body weight) considerably reduced the PH-induced changes in liver structures. Ethanol treatment also decreased liver thymidine kinase activity, serum albumin, and glucose levels. Intraperitoneal administration of the same ethanol dose to PH rats promoted lesser alterations on liver regeneration. Independently of its administration route, ethanol abruptly shortened a PH-induced selective increase in serum enzyme activities. These data suggest that the inhibitory effect of a low dose of ethanol on PH-induced liver regeneration is dependent on the timing and route of administration.
KW - Alcohol
KW - Hepatectomy
KW - Liver enzyme release
KW - Liver function
KW - Mitotic index
KW - Thymidine kinase activity
UR - http://www.scopus.com/inward/record.url?scp=0032714291&partnerID=8YFLogxK
U2 - 10.1023/A:1026601814082
DO - 10.1023/A:1026601814082
M3 - Artículo
SN - 0163-2116
VL - 44
SP - 1963
EP - 1974
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 10
ER -