TY - JOUR
T1 - Molecular characterization of atypical antigenic variants of canine rabies virus reveals its reintroduction by wildlife vectors in southeastern Mexico
AU - Garcés-Ayala, Fabiola
AU - Aréchiga-Ceballos, Nidia
AU - Ortiz-Alcántara, Joanna M.
AU - González-Durán, Elizabeth
AU - Pérez-Agüeros, Sandra I.
AU - Méndez-Tenorio, Alfonso
AU - Torres-Longoria, Belem
AU - López-Martínez, Irma
AU - Hernández-Rivas, Lucía
AU - Díaz-Quiñonez, José Alberto
AU - Ramírez-González, José Ernesto
N1 - Publisher Copyright:
© 2017, Springer-Verlag GmbH Austria.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Rabies is an infectious viral disease that is practically always fatal following the onset of clinical signs. In Mexico, the last case of human rabies transmitted by dogs was reported in 2006 and canine rabies has declined significantly due to vaccination campaigns implemented in the country. Here we report on the molecular characterization of six rabies virus strains found in Yucatan and Chiapas, remarkably, four of them showed an atypical reaction pattern when antigenic characterization with a reduced panel of eight monoclonal antibodies was performed. Phylogenetic analyses on the RNA sequences unveiled that the three atypical strains from Yucatan are associated with skunks. Analysis using the virus entire genome showed that they belong to a different lineage distinct from the variants described for this animal species in Mexico. The Chiapas atypical strain was grouped in a lineage that was considered extinct, while the others are clustered within classic dog variants.
AB - Rabies is an infectious viral disease that is practically always fatal following the onset of clinical signs. In Mexico, the last case of human rabies transmitted by dogs was reported in 2006 and canine rabies has declined significantly due to vaccination campaigns implemented in the country. Here we report on the molecular characterization of six rabies virus strains found in Yucatan and Chiapas, remarkably, four of them showed an atypical reaction pattern when antigenic characterization with a reduced panel of eight monoclonal antibodies was performed. Phylogenetic analyses on the RNA sequences unveiled that the three atypical strains from Yucatan are associated with skunks. Analysis using the virus entire genome showed that they belong to a different lineage distinct from the variants described for this animal species in Mexico. The Chiapas atypical strain was grouped in a lineage that was considered extinct, while the others are clustered within classic dog variants.
UR - http://www.scopus.com/inward/record.url?scp=85027875338&partnerID=8YFLogxK
U2 - 10.1007/s00705-017-3529-4
DO - 10.1007/s00705-017-3529-4
M3 - Artículo
C2 - 28819692
SN - 0304-8608
VL - 162
SP - 3629
EP - 3637
JO - Archives of Virology
JF - Archives of Virology
IS - 12
ER -